Disorders of migration and gyration

Der Radiologe
I Pogledic

Abstract

Disorders of migration and gyration are a versatile group of pathologies that may cause epilepsy and/or neurodevelopmental delay. With the recent improvement of imaging methods, it is possible to detect these pathologies, not only on postnatal MRI but also in utero using fetal MRI. The use of MRI together with genetic tests and knowledge of the classification of these malformations makes early diagnosis possible. Furthermore, the exact diagnosis of disorders of gyration and migration will help ensure better treatment of symptomatic epilepsies as well as be of great help in counselling the parents if detected in utero. Ultimately, it may enable the development of new treatment strategies. Therefore, in this review the fetal neuroanatomy and pathologies due to migration and abnormal postmigratory processes together with the recent classification of these malformations are elucidated, which will ensure early diagnosis of these types of developmental disorders.

References

Feb 2, 2002·Nature Reviews. Neuroscience·Pasko Rakic
Mar 16, 2006·Current Opinion in Neurology·Pierre Gressens
Jan 23, 2008·Nature Reviews. Neuroscience·Irina BystronPasko Rakic
May 21, 2011·Seminars in Ultrasound, CT, and MR·Beth M Kline-Fath, Maria A Calvo-Garcia
Feb 2, 2013·Der Radiologe·I PogledicW Reith
May 27, 2014·Brain : a Journal of Neurology·Nadia Bahi-BuissonJamel Chelly
Nov 14, 2015·AJNR. American Journal of Neuroradiology·C A MutchA J Barkovich
Nov 20, 2016·Annals of Neurology·Rahul S Desikan, A James Barkovich

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