PMID: 6987931Apr 1, 1980Paper

Disorders of phagocyte chemotaxis

Annals of Internal Medicine
J I GallinC H Kirkpatrick

Abstract

Recent advances in understanding the physiologic and biochemical bases for recruitment of phagocytes to inflammatory sites has led to the recognition of patients who have recurrent infections because of abnormalities of phagocyte chemotaxis. In some of these patients there is abnormal chemoattractant mediator production or regulation, whereas in others there are defects in phagocytic cell function. The cellular defects in chemotaxis can be characterized as either intrinsic defects of the cellular motility apparatus or acquired defects from mediators influencing cell function or from shifts in circulating phagocyte subpopulations. Systematic study of these defects has resulted in functional, biochemical, and ultrastructural characterization of abnormal phagocyte chemotaxis in certain patients, and in some patients study has led to rational approaches for treatment. Clinical trials assessing the efficacy of such pharmacologic agents are underway.

Citations

Jan 1, 1980·Infection·R R Kretschmer, M L Collado
Jan 1, 1981·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·F PatroneG Lanzi
Jan 1, 1981·Springer Seminars in Immunopathology·P G Quie
Jan 1, 1982·Medical Microbiology and Immunology·F PatroneC Sacchetti
Jan 1, 1983·Annals of Biomedical Engineering·C Rothman, D Lauffenburger
Mar 1, 1995·The Annals of Thoracic Surgery·R A HallL R Kaiser
Jan 1, 1981·Journal of Immunological Methods·T M Schaack, R H Persellin
Mar 1, 1983·Veterinary Immunology and Immunopathology·G S Smith, J H Lumsden
Jul 4, 2001·Biochemical Pharmacology·G A CerchiaroP Sannomiya
Jul 29, 1982·The New England Journal of Medicine·H DonabedianJ I Gallin
Feb 1, 1986·Cell Biophysics·R T Tranquillo, D A Lauffenburger
Aug 1, 1985·Pathology, Research and Practice·H Keller, H Cottier
Nov 1, 1987·Diabetes Research and Clinical Practice·M NaghibiP B Michelsen
Jul 1, 1994·Oral Surgery, Oral Medicine, and Oral Pathology·S R Porter, C Scully
Oct 30, 2001·The Veterinary Journal·S ComazziP Sartorelli
Nov 15, 2000·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S PaltrinieriP Sartorelli
Oct 12, 2005·The Journal of Cell Biology
Nov 1, 1986·The Journal of Allergy and Clinical Immunology·R S Geha, D Y Leung
Mar 1, 1986·The British Journal of Surgery·J P DuignanD Bouchier-Hayes
Sep 1, 1991·Veterinary Pathology·J M MadduxW L Sanders
Feb 1, 1985·Journal of Oral Pathology·J A CharonJ I Gallin
Jul 1, 1988·The British Journal of Dermatology·D ShuttleworthN Mathews
Jun 1, 1989·Clinical Otolaryngology and Allied Sciences·L A Smallman
Dec 1, 1983·European Journal of Clinical Investigation·N H ValeriusM Pedersen
Dec 1, 1980·Hospital Practice·P G Quie, S D Douglas
May 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C H Kirkpatrick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.