PMID: 45476Jan 1, 1977

Disorders of phagocyte function: biochemical aspects

Progress in Clinical and Biological Research
P G Quie


Intensive laboratory investigation of patients with recurrent infections, and with infections with microbial species not usually considered to be pathogenic, have led to the identification of several defects in granulocyte function. The two functions of granulocytes which have received most attention in the past decade have been locomotion (especially response to chemotactic stimulation) and microbicidal activity. Defective granulocyte chemotaxis has been demonstrated in patients with clinical manifestations suggesting abnormalities related to vasoactive amines, i.e., patients with eczema and extreme IgE hyperimmunoglobulinemia. The depressed granulocyte chemotactic responsiveness found in these patients can be reproduced in vitro when histamine and beta adrenergic agents are incubated with control granulocytes. Since these compounds have been shown to increase levels of intracellular cyclic AMP in other cells, there appears to be an association between cyclic nucleotide metabolism and regulation of granulocyte locomotion. Defective granulocyte microbicidal activity is found in patients with chronic granulomatous disease and it has been shown that there is little increase in oxidative metabolism during phagocytosis by these cel...Continue Reading

Related Concepts

Histamine Measurement
Inborn Errors of Metabolism
Hydrogen Peroxide
Cell Motility
Pathogenic Organism
Depressed - Symptom
Cyclic Nucleotide Metabolic Process
Phagocyte Bactericidal Dysfunction

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