Disorders of sexual development in the domestic horse, Equus caballus

Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
T L Lear, R B McGee

Abstract

Abnormalities of sexual development causing infertility in horses have been investigated since the early 1970's. Conventional cytogenetic analysis by karyotyping has been the primary tool used to investigate these horses. Abnormalities have a broad range, from a phenotypically normal mare with gonadal dysgenesis to a horse with ambiguous external genitalia and internal male and female organs. Cytogenetic analysis can determine genetic sex but cannot identify mutations or deletions of genes involved in the sex determination pathway. Molecular technologies have been developed to confirm cytogenetic results and to aid in identifying the genetic causes of abnormal sex determination in horses. In this paper, we review the historical development of methods used to understand abnormal sexual development in the horse as well as summarize cases reported over the last 40-50 years.

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Feb 18, 2016·Annual Review of Animal Biosciences·Terje Raudsepp, Bhanu P Chowdhary
Jul 29, 2016·The Journal of Endocrinology·C J CorbinA J Conley
Dec 2, 2016·Reproduction in Domestic Animals = Zuchthygiene·Jesús DoradoS Demyda-Peyrás
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Aug 3, 2018·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Stefanie NeuhauserAldona Pieńkowska-Schelling
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Jun 15, 2020·The Veterinary Clinics of North America. Equine Practice·Terje Raudsepp
Apr 4, 2021·Animals : an Open Access Journal From MDPI·M Bugno-Poniewierska, Terje Raudsepp

Related Concepts

Horse Diseases
Hypospadias
Karyotype Determination Procedure
Mosaicism
Sex Chromosomes
Intersexuality
Sex Chromosome Disorders of Sex Development
Gene Deletion
Genes
Genitalia

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