Disorders of the autonomic nervous system in patients with Brugada syndrome: a pilot study

Journal of Cardiovascular Electrophysiology
Anna KostopoulouDennis Cokkinos

Abstract

The aim of this study was to examine autonomic disorders in patients with Brugada syndrome by performing a cardiac sympathetic innervation evaluation, a head-up tilt-test (HUT) and heart rate variability (HRV) analysis. We enrolled 20 patients with Brugada syndrome (mean age 42.5 +/- 8.8 years), 9 with spontaneous and 11 with an induced type 1 electrocardiogram (ECG) in the setting of symptoms and 20 age-matched controls. All subjects underwent a HUT with parallel measurements of plasma catecholamines and cortisol, a (123)I-metaiodobenzylguanidine single photon emission tomography, and HRV evaluation. Ten control subjects participated in the innervation portion of the study. The tilt-test with clomipramine challenge was positive in 15 of 20 (75%) patients (7 spontaneous, 8 induced) and in 1 in controls (P < 0.01). A sympathoadrenal imbalance was shown in positive tests. The pattern of innervation in all groups was heterogenic and similar to controls with a trend towards lower measurements in patients with a spontaneous type 1 ECG and a positive HUT. HRV analysis did not reveal any significant differences during day and night. Four patients (20%) had sustained ventricular arrhythmias during a follow-up of 31.1 +/- 8.6 months, bu...Continue Reading

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Aug 7, 2012·Current Treatment Options in Cardiovascular Medicine·Jennifer N A Silva, Jonathan R Silva
Jun 1, 2012·Cardiac Electrophysiology Clinics·Troy Rhodes, Raul Weiss
Dec 29, 2011·Cardiology Research and Practice·Aimé BonnyGuy Fontaine
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May 15, 2013·International Journal of Cardiology·Eleonora TobaldiniVirend K Somers
Jan 31, 2017·Physiological Measurement·M CalvoA Hernández

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