Disorders of the respiratory muscles

American Journal of Respiratory and Critical Care Medicine
Franco Laghi, M J Tobin

Abstract

The act of breathing depends on coordinated activity of the respiratory muscles to generate subatmospheric pressure. This action is compromised by disease states affecting anatomical sites ranging from the cerebral cortex to the alveolar sac. Weakness of the respiratory muscles can dominate the clinical manifestations in the later stages of several primary neurologic and neuromuscular disorders in a manner unique to each disease state. Structural abnormalities of the thoracic cage, such as scoliosis or flail chest, interfere with the action of the respiratory muscles-again in a manner unique to each disease state. The hyperinflation that accompanies diseases of the airways interferes with the ability of the respiratory muscles to generate subatmospheric pressure and it increases the load on the respiratory muscles. Impaired respiratory muscle function is the most severe consequence of several newly described syndromes affecting critically ill patients. Research on the respiratory muscles embraces techniques of molecular biology, integrative physiology, and controlled clinical trials. A detailed understanding of disease states affecting the respiratory muscles is necessary for every physician who practices pulmonary medicine or ...Continue Reading

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References

Mar 1, 1977·Medicine·L LohJ N Davis
Jan 1, 1976·European Journal of Intensive Care Medicine·N BuchananC D Eyberg
Jan 11, 1975·Respiration; International Review of Thoracic Diseases·M ArboreliusJ Senyk
May 1, 1992·Circulation·H DrexlerH Just
Aug 20, 1992·The New England Journal of Medicine·V SegredoR D Miller
Aug 1, 1992·The American Review of Respiratory Disease·J A DouglassG Bowes
Jul 1, 1992·The American Review of Respiratory Disease·V NinaneA De Troyer
Sep 11, 1992·Journal of Applied Physiology·J K LanzM Ontell
Oct 1, 1992·The American Review of Respiratory Disease·N M SiafakasD Bouros
Nov 1, 1992·The American Review of Respiratory Disease·S NavaC Rampulla
Dec 1, 1992·The American Review of Respiratory Disease·A Jubran, M J Tobin
Jan 1, 1992·Annals of Neurology·M A Quera-SalvaP Gajdos
Apr 11, 1992·Journal of Applied Physiology·J M WalshJ T Sharp
Apr 1, 1992·Brain : a Journal of Neurology·R S HowardJ Newsom-Davis
Jul 1, 1992·The American Review of Respiratory Disease·T T TrangM Aubier
Feb 1, 1992·The American Review of Respiratory Disease·C TantucciJ Milic-Emili
Nov 1, 1991·The Journal of Physiology·D MaskillA Guz
Sep 26, 1991·The New England Journal of Medicine·T SimilowskiF Bellemare
Oct 1, 1991·The American Review of Respiratory Disease·G ContrerasC Lisboa
Jan 1, 1991·The American Review of Respiratory Disease·T WankeK Irsigler
May 1, 1991·The American Review of Respiratory Disease·P Bégin, A Grassino
Apr 1, 1990·Thorax·P T ByeC E Sullivan
Aug 1, 1990·Medicine and Science in Sports and Exercise·R B Armstrong
Jul 1, 1989·The American Review of Respiratory Disease·G E TzelepisF G Hoppin
May 1, 1989·The American Review of Respiratory Disease·M EstenneA De Troyer
Jun 1, 1989·Journal of Applied Physiology·G C Sieck, M Fournier
Aug 1, 1989·Annals of the Rheumatic Diseases·D VanderschuerenJ Dequeker
Mar 1, 1989·The American Journal of Physiology·Y FongA Cerami

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Citations

Mar 16, 2007·Intensive Care Medicine·Dries TestelmansGhislaine Gayan-Ramirez
Jul 17, 2008·Intensive Care Medicine·Franco Laghi
Mar 17, 2010·Intensive Care Medicine·Amal JubranMartin J Tobin
Nov 25, 2011·Intensive Care Medicine·Michael J BannerAndrea Gabrielli
Mar 4, 2005·Current Neurology and Neuroscience Reports·Ibrahim Oztura, Christian Guilleminault
Apr 17, 2008·European Journal of Anaesthesiology. Supplement·O Friedrich
Sep 21, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M ChlifS Ahmaidi
Mar 9, 2012·The New England Journal of Medicine·F Dennis McCool, George E Tzelepis
Nov 26, 2013·Brain : a Journal of Neurology·A Reghan FoleyCarsten G Bönnemann
Sep 22, 2007·Critical Care Medicine·Katarina Fredriksson, Olav Rooyackers
Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Oliver Friedrich
Feb 4, 2006·Current Opinion in Pulmonary Medicine·Vijay P Balasubramanian, Basil Varkey
May 30, 2013·Current Opinion in Pulmonary Medicine·Nadir Kharma
Apr 14, 2012·Current Opinion in Pediatrics·Nanci Yuan
Mar 28, 2006·Thorax·D E O'Donnell, C M Parker
Jul 17, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gerald S SupinskiLeigh Ann Callahan
Aug 8, 2009·Journal of Applied Physiology·G S SupinskiL A Callahan
Nov 13, 2010·Journal of Applied Physiology·G S Supinski, L A Callahan
Nov 15, 2012·Pulmonary Medicine·D PapandrinopoulouG Tsoukalas
Feb 9, 2006·Respiration; International Review of Thoracic Diseases·M ReiterT Wanke
Apr 14, 2006·Respiration; International Review of Thoracic Diseases·Anat RatnovskyMordechai R Kramer
Mar 22, 2005·American Journal of Respiratory and Critical Care Medicine·Thierry TroostersMarc Decramer
Dec 14, 2004·American Journal of Respiratory and Critical Care Medicine·Franco LaghiMartin J Tobin
Aug 20, 2005·American Journal of Respiratory and Critical Care Medicine·Robert B GormanSimon C Gandevia
Mar 22, 2005·American Journal of Respiratory and Critical Care Medicine·Thomas BrackMartin J Tobin
Dec 13, 2005·American Journal of Respiratory and Critical Care Medicine·Coen A C OttenheijmP N Richard Dekhuijzen
Aug 19, 2006·American Journal of Respiratory and Critical Care Medicine·Coen A C OttenheijmP N Richard Dekhuijzen
Nov 8, 2008·American Journal of Respiratory and Critical Care Medicine·Hieronymus W H van HeesLeo M A Heunks
Oct 1, 2011·American Journal of Respiratory and Critical Care Medicine·Jonne DoorduinLeo M A Heunks
Jan 14, 2004·American Journal of Respiratory and Critical Care Medicine·Martin J Tobin
Jan 14, 2004·American Journal of Respiratory and Critical Care Medicine·Martin J Tobin
Jan 14, 2004·American Journal of Respiratory and Critical Care Medicine·Martin J Tobin
Mar 9, 2004·American Journal of Respiratory and Critical Care Medicine·Jorge Boczkowski
Mar 31, 2009·American Journal of Respiratory Cell and Molecular Biology·Gerald S Supinski, Leigh Ann Callahan
Sep 1, 2009·American Journal of Respiratory Cell and Molecular Biology·Gerry S SupinskiLeigh Ann Callahan
Jan 26, 2008·Respiratory Research·Coen A C OttenheijmRichard P N Dekhuijzen
Jan 23, 2008·Respiratory Research·Claudio TerzanoAngelo Petroianni
Jan 25, 2013·Multidisciplinary Respiratory Medicine·Dewi Nurul MakhabahNicolino Ambrosino
Oct 2, 2013·Multidisciplinary Respiratory Medicine·Sevinc Sarinc UlasliGaye Ulubay
Dec 17, 2005·Critical Care : the Official Journal of the Critical Care Forum·Odile NoizetStephane Leteurtre
Feb 17, 2009·Critical Care : the Official Journal of the Critical Care Forum·Sheldon Magder
Mar 18, 2010·Critical Care : the Official Journal of the Critical Care Forum·Gerald S SupinskiLeigh Ann Callahan
Jun 11, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Hester van der VaartNick ten Hacken
May 17, 2007·Sports Medicine·Martijn A Spruit, Emiel F M Wouters

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