Disorders of Vascular Permeability.

Annual Review of Pathology
Cindy Park-Windhol, Patricia A D'Amore

Abstract

The endothelial barrier maintains vascular and tissue homeostasis and modulates many physiological processes, such as angiogenesis. Vascular barrier integrity can be disrupted by a variety of soluble permeability factors, and changes in barrier function can exacerbate tissue damage during disease progression. Understanding endothelial barrier function is critical for vascular homeostasis. Many of the signaling pathways promoting vascular permeability can also be triggered during disease, resulting in prolonged or uncontrolled vascular leak. It is believed that recovery of the normal vasculature requires diminishing this hyperpermeable state. Although the molecular mechanisms governing vascular leak have been studied over the last few decades, recent advances have identified new therapeutic targets that have begun to show preclinical and clinical promise. These approaches have been successfully applied to an increasing number of disease conditions. New perspectives regarding how vascular leak impacts the progression of various diseases are highlighted in this review.

References

Oct 1, 1978·The Journal of Cell Biology·N SimionescuG E Palade
Sep 30, 1992·Biochemical and Biophysical Research Communications·B I TermanP Böhlen
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C TiruppathiI Giaever
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A Antonelli-OrlidgeP A D'Amore
Jun 15, 1989·Biochemical and Biophysical Research Communications·N Ferrara, W J Henzel
Sep 7, 1988·Journal of the National Cancer Institute·G SchackertI J Fidler
Aug 12, 1971·The New England Journal of Medicine·J Folkman
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·L P AielloL E Smith
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·E A PierceL E Smith
Jun 1, 1996·Journal of Cardiovascular Pharmacology·R YangH Jin
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·D R SengerM Detmar
Jan 14, 1999·The American Journal of Physiology·S A CunninghamT A Brock
Jan 15, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·M WellnerH Haller
Mar 2, 1999·Biochemical and Biophysical Research Communications·A M DoanesT Finkel
Apr 13, 1999·The American Journal of Physiology·S FischerG F Karliczek
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·M CoradaE Dejana
Nov 2, 1999·Biochemical and Biophysical Research Communications·J TranR S Kerbel

❮ Previous
Next ❯

Citations

Jan 13, 2018·Frontiers in Immunology·Nader Rahimi
Mar 17, 2017·Circulation Research·Krista HeinolainenGeorgia Zarkada
Aug 31, 2017·Cold Spring Harbor Perspectives in Biology·Maria Grazia LampugnaniCostanza Giampietro
May 30, 2019·Physiological Reviews·Nina WettschureckStefan Offermanns
Jun 18, 2019·Critical Care Medicine·Chu-Fan XuLai Jiang
Dec 4, 2019·ELife·Stanislao Igor TravisanoJosé Luis De La Pompa Mínguez
Aug 14, 2018·Signal Transduction and Targeted Therapy·Gui-Li Yang, Lu-Yuan Li
Mar 29, 2018·Histochemistry and Cell Biology·Wei-Hua TangShih-Chieh Chen
Jan 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Fenny H F TangRicardo J Giordano
Aug 22, 2020·Translational Vision Science & Technology·Weiwei JiangWeiquan Zhu
Sep 25, 2018·Frontiers in Immunology·Cosimo BruniSilvia Bellando-Randone
Dec 6, 2018·Biochemical Society Transactions·Lilian Schimmel, Emma Gordon
Oct 6, 2017·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Seung-Sik RhoShigetomo Fukuhara
Oct 13, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ramin RokhzanRamaswamy Krishnan
Jan 11, 2020·Frontiers in Oncology·Dolores Aguilar-CazaresJose S Lopez-Gonzalez
Oct 10, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Victor ChatterjeeSarah Y Yuan
Dec 11, 2020·Tissue Barriers·Mir S AdilPayaningal R Somanath
Jan 1, 2021·Frontiers in Immunology·Vanessa Araujo Gomes SantaterraErich Vinicius De Paula
Oct 20, 2020·Cellular and Molecular Gastroenterology and Hepatology·Chong ZhangJie Yan
Feb 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Athanasios ZiogasDavid Sprott
Nov 17, 2020·Frontiers in Chemistry·Fan XuPengfei Wang
Dec 29, 2020·Frontiers in Bioengineering and Biotechnology·Alexander J BoysRoisin M Owens
Feb 27, 2021·Forensic Science International : Synergy·Masanori IshidaOsamu Abe
Dec 15, 2020·Trends in Molecular Medicine·Lena Claesson-WelshDonald M McDonald
Feb 13, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Ki-Sook ParkBarry M Gumbiner
Apr 4, 2021·Nutrients·Holly ClarkeMichael J Ormsbee
May 1, 2021·International Journal of Molecular Sciences·Akiyoshi Uemura, Yoko Fukushima
Aug 14, 2020·The Science of the Total Environment·Qingqing LiangZhiwei Sun
Jun 4, 2021·Frontiers in Pharmacology·Bruna CaridiPatric Turowski
May 6, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rie ShimotsuYutaka Kano
Jul 3, 2021·International Journal of Molecular Sciences·Jean-Luc Wautier, Marie-Paule Wautier
Sep 29, 2018·Molecular Pharmaceutics·Janine SchnieringCristina Müller

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence microscopy
nucleotide exchange
GTPase
GTPases
transmission electron microscopy
light microscopy

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Blood Brain Barrier & Cytokines

Some cytokines are able to cross the blood brain barrier through transport systems and enter the cerebrospinal fluid and interstitial fluid spaces. Here is the latest research on cytokines crossing the blood brain barrier and how this can affect tissues within the CNS.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Caveolins & Signal Transduction

Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Annual Review of Biomedical Engineering
Timothy P PaderaLance L Munn
Annual Review of Physiology
Anna UrygaMartin Bennett
Annual Review of Biochemistry
Yosef Gruenbaum
Annual Review of Pharmacology and Toxicology
Ivone GomesLakshmi A Devi
© 2022 Meta ULC. All rights reserved