Disorganization of gap junction distribution in dilated atria of patients with chronic atrial fibrillation

Circulation Journal : Official Journal of the Japanese Circulation Society
Susumu TakeuchiItsuo Kodama

Abstract

Atrial fibrillation (AF) is an arrhythmia associated with functional and morphological remodeling of atria. We investigated the distribution and the expression of connexins in atrial tissues from patients with chronic AF and left atrial dilatation (AD). Immunohistochemistry was performed in atrial tissues obtained during cardiac surgery from patients with chronic AF + AD (n = 11), sinus rhythm (SR, n = 11) and SR + AD (n = 4). In SR patients (control), the connexin (Cx) 43 labeling of the intercalated disks seen en-face was characterized by small central spots surrounded by larger spots at the periphery. In the left atria from AF + AD patients, the area of the intercalated disk was significantly enlarged. Although peripheral Cx43 labeling was preserved, there was a striking loss of central labeling spots. The area occupied by gap junctions was slightly but significantly larger than that of the control. The left atria from patients with SR + AD showed gap junction disorganization analogous to AF + AD. The labeling patterns of Cx40 were essentially similar to those of Cx43. Conclusions In chronic AF with AD, gap junctions at the intercalated disk are disorganized, resulting most likely from AD but not from AF itself. This gap jun...Continue Reading

References

Nov 1, 1986·Pacing and Clinical Electrophysiology : PACE·M BoutjdirP Peronneau
Sep 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D B Gros, H J Jongsma
Jul 8, 1998·Journal of Cardiovascular Electrophysiology·H M van der VeldenH J Jongsma
Jul 27, 2000·Cardiovascular Research·H M van der VeldenH J Jongsma
Feb 17, 2001·Microscopy Research and Technique·N J SeversD Halliday
Apr 24, 2001·Pflügers Archiv : European journal of physiology·V Valiunas, R Weingart
Aug 31, 2001·Journal of the American College of Cardiology·L PolontchoukS Dhein
Jun 14, 2002·Cardiovascular Research·Huub M W van der Velden, Habo J Jongsma
Jun 14, 2002·Cardiovascular Research·Sawa KostinJutta Schaper
Apr 20, 2004·Cardiovascular Research·Nicholas J SeversTsutomu Matsushita

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Citations

Jun 19, 2009·Cardiovascular Research·Sevasti-Maria ChaldoupiHarold V M van Rijen
Dec 3, 2010·Cardiovascular Research·Saagar MahidaPatrick T Ellinor
Mar 17, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Sevasti-Maria ChaldoupiToon A B van Veen
Sep 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Min TangCongxin Huang
Feb 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Chieko SasanoItsuo Kodama
May 29, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Teun P de BoerToon A B van Veen
Jan 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Hidehira FukayaTohru Izumi
Dec 15, 2015·Nature Reviews. Cardiology·Liang-Han LingRoss J Hunter
Apr 2, 2008·Progress in Biophysics and Molecular Biology·Jens EcksteinUlrich Schotten
Aug 25, 2012·Progress in Biophysics and Molecular Biology·Saurabh KumarJonathan M Kalman
Nov 2, 2014·Cell and Tissue Research·Pier D Lambiase, Andrew Tinker
Jan 7, 2014·International Journal of Cardiology·Eleftherios M KallergisPanos E Vardas
Apr 22, 2017·Clinical and Experimental Pharmacology & Physiology·Xin LiShu-Lin Wu
Feb 2, 2012·Circulation. Arrhythmia and Electrophysiology·Ross J HunterRichard J Schilling
Dec 14, 2011·Circulation·Takeshi KatoStanley Nattel
Aug 25, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Melanie A Zile, Natalia A Trayanova
Jan 21, 2011·Physiological Reviews·Ulrich SchottenAndreas Goette
Oct 31, 2015·Anesthesia and Analgesia·Daisuke MaruyamaMichiaki Yamakage

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