Disorganized retinal lamellar structures in nonperfused areas of diabetic retinopathy

Investigative Ophthalmology & Visual Science
Yoko DodoNagahisa Yoshimura

Abstract

To investigate morphologic changes on spectral-domain optical coherence tomography (SD-OCT) images in nonperfused areas (NPAs) in diabetic retinopathy (DR). One hundred eight consecutive eyes of 80 patients with diabetic ischemic maculopathy were retrospectively reviewed. The boundary between the nerve fiber layer (NFL) and the ganglion cell layer (GCL)/inner plexiform layer (IPL) and the status of Henle's layer were characterized on the vertical sectional images of SD-OCT. These findings were compared with the NPAs on the FA images and the logMAR visual acuity (VA). The SD-OCT images showed that most areas of capillary nonperfusion had an indistinct boundary between the NFL and GCL/IPL in DR, regardless of high or moderate OCT reflectivity. The total transverse length of the NPAs was correlated positively with that of the areas with no boundary between these layers in all 108 eyes (R = 0.860, P < 0.001). Sixty-four eyes that had center-involved diabetic macular edema (DME) also had a significant association between them (R = 0.764, P < 0.001), and the most significant correlation was seen in eyes without DME (R = 0.955, P < 0.001). The macular transverse length of the areas with no boundary between the NFL and GCL/IPL was asso...Continue Reading

Citations

Nov 11, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Thomas W Gardner, Jose R Davila
Apr 18, 2019·Investigative Ophthalmology & Visual Science·Kazuya MorinoAkitaka Tsujikawa
Aug 28, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Alejandro FonollosaMiguel Angel Zapata
Apr 19, 2017·Ophthalmic Surgery, Lasers & Imaging Retina·Dilraj S GrewalGlenn J Jaffe
Mar 20, 2019·Scientific Reports·Tatsuya YoshitakeAkitaka Tsujikawa
Jan 15, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Xiangji PanJuan Ye
Jan 12, 2021·Progress in Retinal and Eye Research·Warren W PanPatrice E Fort
Dec 11, 2020·Journal of Diabetes Research·Alessia AmatoFrancesco Bandello

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