Disoriented pathfinding by pioneer neurone growth cones deprived of filopodia by cytochalasin treatment

Nature
D Bentley, A Toroian-Raymond

Abstract

A major question in developmental neurobiology is how developing nerve cells accurately extend processes to establish connections with their target cells. This problem involves both the nature of cues for growth cone guidance and also the question of how growth cones survey their environment for cues and respond by altering their direction of migration. The filopodia which normally extend from neuronal growth cones have been shown to affect growth cone steering in vitro and it has been proposed that they function in vivo in the detection of and response to guidance cues. This hypothesis could be tested in vivo if growth cones which normally have filopodia could be induced to migrate in their absence. The pair of Ti1 neurones are the first neurones to extend axons through the limb buds of embryonic grasshoppers. We report here an examination of the migration of Ti1 pioneer growth cones deprived of filopodia by culture in agents which disrupt actin microfilaments. Under these conditions, axons continue to extend but a large percentage of growth cones are highly disoriented. Our results indicate that Ti1 filopodia are not necessary for axonal elongation in vivo but that they are important for correctly oriented growth cone steering.

References

Aug 1, 1978·Experimental Cell Research·N K Wessells, R P Nuttall
Mar 4, 1976·Nature·C M Bate
Jan 1, 1985·Journal of Neuroscience Research·C A Mason
Jun 1, 1971·The Journal of Cell Biology·K M YamadaN K Wessells
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·V LoprestiC Levinthal
Dec 1, 1984·The Journal of Cell Biology·L Marsh, P C Letourneau
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L Y Jan, Y N Jan
Jan 1, 1981·Annual Review of Neuroscience·D Bray, D Gilbert
Dec 10, 1982·Science·D Bentley, H Keshishian

❮ Previous
Next ❯

Citations

Jan 1, 1996·Cell Motility and the Cytoskeleton·S M Burden-Gulley, V Lemmon
Sep 1, 1996·Journal of Neurobiology·R W DavenportS B Kater
Feb 19, 1998·Journal of Neurobiology·V Rehder, S Cheng
Nov 28, 2000·Cell Motility and the Cytoskeleton·S ChengV Rehder
Aug 10, 2000·Journal of Neurobiology·G Gallo, P C Letourneau
Jan 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J A Davies, G M Cook
Jan 1, 1992·Cell Motility and the Cytoskeleton·H R PayneV Lemmon
Jan 1, 1995·Cell Motility and the Cytoskeleton·H M Buettner
Jan 17, 2002·Journal of Neurobiology·Francisco F de-Miguel, Javier Vargas
Mar 14, 2002·Journal of Neurobiology·Su ChengVincent Rehder
Jan 1, 1989·Molecular Neurobiology·C O Van HooffW H Gispen
Jan 1, 1987·Molecular Neurobiology·A D Lander
May 7, 2013·European Biophysics Journal : EBJ·Philipp RauchJosef A Käs
Oct 12, 2012·Histochemistry and Cell Biology·Laura OlbrichCarsten Theiss
Mar 11, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Oveis KarimaAli Akbar Moosavi Movahedi
Jan 1, 1988·Tissue & Cell·D Fristrom
Jan 1, 1989·Brain Research. Developmental Brain Research·N R Smalheiser
Apr 1, 1990·Brain Research. Developmental Brain Research·M A Cambray-DeakinR D Burgoyne
Jun 19, 1992·Brain Research. Developmental Brain Research·N A Rashid, M A Cambray-Deakin
Jul 1, 1988·Trends in Neurosciences·S B KaterJ Connor
Jul 1, 1989·Trends in Neurosciences·P R Gordon-Weeks
Nov 1, 1989·Trends in Neurosciences·P Forscher
Jan 1, 1988·Progress in Neurobiology·C D McCaig
Jan 1, 1989·Progress in Neurobiology·R D FieldsM H Ellisman
Jun 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D M SnowP C Letourneau
Oct 1, 1994·Current Opinion in Neurobiology·C H LinP Forscher
Feb 1, 1995·Current Opinion in Neurobiology·S B Kater, V Rehder
Oct 29, 2003·Biophysical Journal·Feng-Song WangDaniel G Jay
Apr 29, 1998·Progress in Neurobiology·M Akinori
Oct 10, 1997·Gene·M FukuokaT Takenawa
Jun 29, 2001·Mechanisms of Development·C E Krull
Feb 1, 1997·Current Opinion in Neurobiology·L LuoY N Jan
Jun 19, 2002·Biochimica Et Biophysica Acta·C L SayasF Wandosell
Jul 2, 2003·Nature Cell Biology·Olga C RodriguezClare M Waterman-Storer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.