PMID: 11322170Apr 27, 2001Paper

Disparate E-cadherin mutations in LCIS and associated invasive breast carcinomas

Molecular Pathology : MP
K M Rieger-ChristI C Summerhayes

Abstract

The relation between lobular carcinoma in situ (LCIS) and invasive breast cancer is unresolved. In an attempt to establish whether LCIS is a precursor of invasive cancer the mutational status and the expression of E-cadherin was analysed in LCIS and associated invasive breast carcinoma in 23 patients. Foci of LCIS and associated invasive carcinoma were individually microdissected from tissue from 23 patients. Exons 4-16 of the E-cadherin gene were analysed using single strand conformation polymorphism (SSCP); protein expression and the localisation of E-cadherin and beta-catenin were assessed with the use of immunohistochemistry. Immunohistochemistry revealed a lack of expression of E-cadherin and beta-catenin in most LCIS samples and invasive foci. In all but four cases, the staining pattern was identical in the LCIS and associated invasive areas. When E-cadherin was absent, beta-catenin was also undetected, suggesting a lack of expression of alternative classic cadherin members in these lesions. Coincident E-cadherin mutations in LCIS and associated invasive carcinoma were not identified in this series of patients. However, mutational analysis of E-cadherin in multiple foci of carcinoma in situ surrounding an invasive lesion ...Continue Reading

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Feb 15, 2001·Human Pathology·K M Rieger-ChristI C Summerhayes

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Citations

Nov 15, 2011·Breast Cancer Research and Treatment·Mary MorroghTari A King
Dec 22, 2006·Journal of Clinical Pathology·Jorge S Reis-Filho, Sarah E Pinder
Jan 17, 2007·Breast Cancer Research : BCR·Stephen J ChanockAnne-Lise Børresen-Dale
Jul 11, 2012·Breast Cancer Research : BCR·Victor P AndradeTari A King
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Haixin LeiIgor Vorechovský
Jun 5, 2015·Breast Cancer Research : BCR·Greg J LoganPriscilla F McAuliffe
May 29, 2016·Pathology, Research and Practice·Matthias ChristgenHans Kreipe
Nov 5, 2016·Cellular Signalling·Toshiaki TanakaMitsuyoshi Iino
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul J ChubaAmr Aref
Mar 18, 2017·Scientific Reports·Denggang FuBrian Z Ring
Jul 22, 2006·Advances in Anatomic Pathology·Melinda F Lerwill
Jul 15, 2004·The American Journal of Surgical Pathology·Melinda F Lerwill
Sep 20, 2005·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Gulisa TurashviliZdenek Kolár
Feb 8, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Teresa L MastracciIrene L Andrulis
Sep 28, 2010·The American Journal of Surgical Pathology·Emad A RakhaIan O Ellis
Sep 16, 2006·Annual Review of Entomology·Felix L WäckersPaul van Rijn
Aug 1, 2009·Archives of Pathology & Laboratory Medicine·Alejandro Contreras, Husain Sattar

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