Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction.

Proceedings of the National Academy of Sciences of the United States of America
Lauren K ElyJamie Rossjohn

Abstract

The underlying basis of major histocompatibility complex (MHC) restriction is unclear. Nevertheless, current data suggest that a common thermodynamic signature dictates alphabeta T cell receptor (TcR) ligation. To evaluate whether this thermodynamic signature defines MHC restriction, we have examined the thermodynamic basis of a highly characterized immunodominant TcR interacting with its cognate peptide-MHC-I ligand. Surprisingly, we observed this interaction to be governed by favorable enthalpic and entropic forces, which is in contrast to the prevailing generality, namely, enthalpically driven interactions combined with markedly unfavorable entropic forces. We conclude that extrinsic molecular factors, such as coreceptor ligation, conformational adjustments involved in TcR signaling, or constraints dictated by higher-order arrangement of ligated TcRs, might play a greater role in guiding MHC restriction than appreciated previously.

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·H NaghibiJ M Sturtevant
Aug 16, 1996·Science·B C SimN R Gascoigne
May 23, 1998·Annual Review of Immunology·M M DavisY Chien
Feb 19, 1999·Immunity·D N Garboczi, W E Biddison
Apr 16, 1999·Immunity·B E WillcoxP A van der Merwe
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·J J BonifaceM M Davis
Aug 31, 2000·Methods : a Companion to Methods in Enzymology·M J Sanderson
Mar 23, 2001·Nature Immunology·J B ReiserG Mazza
Jan 16, 2002·Current Opinion in Immunology·Markus G Rudolph, Ian A Wilson
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lars Kjer-NielsenJamie Rossjohn
Nov 28, 2002·Acta Crystallographica. Section D, Biological Crystallography·Craig S ClementsJamie Rossjohn
Mar 5, 2003·Annual Review of Immunology·P Anton van der Merwe, Simon J Davis
Jun 11, 2003·Nature Immunology·Guillaume B E Stewart-JonesE Yvonne Jones
Jan 27, 2005·Journal of Molecular Biology·Rebecca L Davis-HarrisonBrian M Baker
Feb 18, 2005·Nature Immunology·Michelle Krogsgaard, Mark M Davis
Apr 20, 2005·The Journal of Experimental Medicine·Ji-Li ChenVincenzo Cerundolo
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lauren K ElyScott R Burrows
Aug 13, 2005·Cell·K Christopher Garcia, Erin J Adams
Aug 25, 2005·IUBMB Life·Lauren K ElyJamie Rossjohn

❮ Previous
Next ❯

Citations

Aug 30, 2008·Immunologic Research·Edward J Collins, David S Riddle
Nov 18, 2006·Nature Reviews. Immunology·Stephen J TurnerJamie Rossjohn
Nov 17, 2007·Nature Reviews. Immunology·Nathan J Felix, Paul M Allen
Oct 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dmitry M GakamskyIsrael Pecht
Oct 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wolfgang W A Schamel, Michael Reth
Jan 2, 2014·Journal of Molecular Biology·Jaafar N HaidarZhiping Weng
Jun 16, 2009·Current Opinion in Immunology·Stephen J TurnerPeter C Doherty
Jul 28, 2012·European Journal of Immunology·Eva B AllerbringAdnane Achour
Sep 18, 2007·Journal of Theoretical Biology·Hugo A van den BergAndrew K Sewell
Sep 11, 2007·Journal of Molecular Biology·Peter J MillerEdward J Collins
May 25, 2007·Seminars in Immunology·Catherine Mazza, Bernard Malissen
May 23, 2008·Journal of Molecular Recognition : JMR·Kathryn M ArmstrongBrian M Baker
Nov 3, 2011·Immunology·John S BridgemanDavid K Cole
Jan 1, 2014·Protein Science : a Publication of the Protein Society·Mugdha BhatiJamie Rossjohn
Oct 3, 2006·Current Opinion in Structural Biology·Craig S ClementsJamie Rossjohn
Jan 22, 2008·Current Opinion in Immunology·Stephanie GrasJamie Rossjohn
Jan 27, 2009·Immunity·Stephanie GrasJamie Rossjohn
Dec 11, 2014·Annual Review of Immunology·Jamie RossjohnJames McCluskey
Apr 10, 2007·Cell·Leremy A ColfK Christopher Garcia
Mar 17, 2007·The EMBO Journal·Catherine MazzaBernard Malissen
Jan 18, 2008·Journal of Molecular Recognition : JMR·Oksana Okhrimenko, Ilian Jelesarov
Dec 13, 2007·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
Feb 14, 2007·European Journal of Immunology·Jonathan M BoulterAwen M Gallimore
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·John J MilesScott R Burrows
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lavanya KrishnanDinakar M Salunke
Sep 20, 2008·The Biochemical Journal·Kathryn M ArmstrongBrian M Baker
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lindsay L JonesDavid M Kranz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.