Dispelling the myth: appropriate use of poly-L-lactic acid and clinical considerations

Journal of the European Academy of Dermatology and Venereology : JEADV
N J Lowe

Abstract

Injectable poly-L-lactic acid (PLLA; Sculptra) is widely used throughout Europe and the USA to restore volume in depressed areas of the face by stimulating neocollagenesis. Injectable PLLA was previously marketed as New-Fill, which was often injected incorrectly and at too high a concentration, resulting in some physicians losing confidence in this product. Today, Sculptra is still regarded with a degree of scepticism by some physicians, due to direct or indirect experience with New-Fill. Sculptra, both in formulation and use, is vastly superior to New-Fill and clinical experience with this product dispels the myths associated with the earlier types of injectable PLLA. PLLA is a very safe, biodegradable compound that has been used in a wide range of medical devices for the last 30 years. In injectable form a good safety profile has been proven; however, when the device is overconcentrated, localized overstimulation of the fibroblasts can result in the formation of small lumps (subcutaneous papules), which are non-pathological but nevertheless palpable by the patient. Physicians must also be trained in the injection of this device, as incorrect injection technique can cause device-related adverse events. New product guidelines h...Continue Reading

References

Nov 24, 2004·Clinics in Dermatology·Gregor B E Jemec, Barbara Jemec

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Citations

Mar 21, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Nicholas J LoweRickie Patnaik
May 15, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Rosemarie Mazzuco, Doris Hexsel
Dec 31, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Melanie D PalmMitchel P Goldman
Jul 5, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sabrina G Fabi, Mitchel P Goldman
Oct 9, 2013·Journal of the American Academy of Dermatology·C William HankeLuitgard G Wiest
Aug 30, 2011·Maturitas·Deanne Mraz Robinson, Sumaira Z Aasi
May 13, 2008·Clinics in Dermatology·Daphne Thioly-Bensoussan
Feb 1, 2011·Dermatologic Therapy·Rebecca Fitzgerald, Danny Vleggaar
Dec 3, 2009·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·David J Goldberg
Mar 16, 2011·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Philippa LoweRickie Patnaik
Apr 23, 2013·Journal of the American Academy of Dermatology·C William Hanke
Mar 12, 2008·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Nick J Lowe
Oct 27, 2017·Journal of the Royal Society, Interface·Jonas HåkanssonL Christoffer Johansson

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