PMID: 8594042Nov 1, 1995Paper

Dispersion of aerosol boluses in the human lung: dependence on lung volume, bolus volume, and gender

Journal of Applied Physiology
J S BrownD E House

Abstract

The dispersion of aerosol boluses in the human lungs has been studied in health and disease, usually as a means of investigating convective mixing. However, there are limited data on the roles of critical factors, such as the volume of inhaled boluses, lung inflation, and gender on dispersion. To examine these factors, we measured the difference in volume variance between exhaled and inhaled boluses (sigma 2V) of a 0.5-micron aerosol in 11 healthy male and 12 healthy female subjects as a function of tidal volume (VT = 1,000 and 1,500 ml in females and 1,000 and 2,000 ml in males), bolus penetration volume (Vi at 250-ml increments over each VT), and bolus volume (target VBol = 75, 150, and 300 ml). Analysis of variance showed marginally significant gender effects (P = 0.073) on sigma 2V, with sigma 2V greater in males than in females. There was also a significant effect of VBol on sigma 2V (P < 0.001). A Vi-dependent mean volume shift between inhaled and exhaled boluses (delta V) was observed at all Vi except 500 ml. The observation of gender and VBol effects and the existence of a nonzero delta V suggest that convective mixing mechanisms other than longitudinal dispersion alone occur in the healthy lung. The lack of VT dependen...Continue Reading

Citations

Dec 8, 1998·Journal of Applied Physiology·J S BrownW D Bennett
Apr 12, 2001·Journal of Applied Physiology·S VerbanckW Vincken
Jun 9, 2012·Journal of Applied Physiology·Baoshun Ma, Chantal Darquenne
Sep 30, 2008·Inhalation Toxicology·Werner HofmannRobert Sturm
Feb 14, 2002·Journal of Applied Physiology·Christopher N MillsG Kim Prisk
Oct 25, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Jakob LöndahlOtmar Schmid
Jun 13, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Chantal Darquenne
Mar 6, 1999·Journal of Applied Physiology·S VerbanckM Paiva
Oct 24, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Holger SchulzJoachim Heyder
Mar 17, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Chien-Wen HuangChien-Hua Huang
Apr 12, 2001·Journal of Applied Physiology·S VerbanckM Paiva
Jun 24, 1999·Inhalation Toxicology·R B DevlinH S Koren

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