Displaced cholinergic, GABAergic amacrine cells in the rabbit retina also contain adenosine

Visual Neuroscience
C Blazynski

Abstract

It is generally accepted that the purine nucleoside, adenosine, plays a neuromodulatory role in the central nervous system (CNS) (Daly et al., 1981; Phillis & Wu, 1983; Williams, 1986; Williams, 1987; Snyder, 1985). Adenosine is thought to exert its primary effects presynaptically, by inhibiting the release of neurotransmitters including gamma-aminobutyric acid (GABA) and acetylcholine (ACh) (Phillis & Barraco, 1985; Proctor & Dunwiddie, 1987). In mammalian retina, cell bodies that are strongly labeled for adenosine-like immunoreactivity (ALIR) have been localized to the ganglion cell layer (GCL) (Braas et al., 1987; Blazynski et al., 1989). Rabbit retinal cells that are labeled by markers for both ACh and GABA are located in the GCL and inner nuclear layer (INL) (Tauchi & Masland, 1984; Vaney & Young, 1988 b; Brecha et al., 1988). It is now demonstrated in the rabbit retina that approximately 50% of the cells labeled for ALIR within the GCL represent true ganglion cells, with the remainder presumed to be displaced cholinergic amacrine cells (DAPI accumulating). In addition, some of these same cells also demonstrate immunoreactivity to glutamate decarboxylase (GAD), involved in the biosynthesis of the neurotransmitter GABA. Thu...Continue Reading

References

Feb 26, 1986·Brain Research·C BlazynskiJ A Ferrendelli
Jan 8, 1985·The Journal of Comparative Neurology·S YazullaC L Zucker
Nov 17, 1987·Brain Research·W R Proctor, T V Dunwiddie
Jan 1, 1985·Annual Review of Neuroscience·S H Snyder
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L O Trussell, M B Jackson
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·N BrechaH Wässle
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K M BraasS H Snyder
Oct 22, 1985·The Journal of Comparative Neurology·J L Mosinger, S Yazulla
Aug 1, 1970·American Journal of Ophthalmology·T KrupinB Becker
Nov 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R H MaslandS A Hayden
Feb 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D I Vaney
Nov 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M Tauchi, R H Masland
Nov 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R H MaslandC Cassidy
Feb 1, 1982·Journal of Neurochemistry·R Paes de Carvalho, F G de Mello
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M C de MelloF G de Mello
Mar 1, 1982·The Journal of Physiology·M Ariel, N W Daw
Jan 1, 1984·Neurochemistry International·B Ehinger, M T Perez

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Citations

Sep 5, 1998·Brain Research. Molecular Brain Research·U BrändleT H Wheeler-Schilling
Jun 14, 2000·Progress in Neurobiology·M P RathboneF Caciagli
Jul 27, 2011·Visual Neuroscience·Kevin J Ford, Marla B Feller
Dec 1, 1994·British Journal of Pharmacology·M Neal, J Cunningham
Oct 1, 1991·Cellular and Molecular Neurobiology·C Blazynski, M T Perez
Jun 20, 2008·Pharmacology & Therapeutics·Almudena CrookeJesús Pintor
Sep 1, 1991·Experimental Eye Research·C L Woods, C Blazynski
Nov 11, 2005·Progress in Neurobiology·Christine L Torborg, Marla B Feller
Dec 14, 1999·Neuron·D StellwagenM B Feller
Mar 18, 2017·Visual Neuroscience·Gudmundur Jonsson, Thor Eysteinsson
Oct 16, 2002·Anais Da Academia Brasileira De Ciências·Roberto Paes-De-Carvalho
May 11, 2000·The Journal of Comparative Neurology·L T Nguyen, N M Grzywacz

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