Displacement analysis of diagnostic ultrasound backscatter: a methodology for characterizing, modeling, and monitoring high intensity focused ultrasound therapy.

The Journal of the Acoustical Society of America
Gavriel SpeyerL A Crum

Abstract

Accurate monitoring of high intensity focused ultrasound (HIFU) therapy is critical for widespread clinical use. Pulse-echo diagnostic ultrasound (DU) is known to exhibit temperature sensitivity through relative changes in time-of-flight between two sets of radio frequency (RF) backscatter measurements, one acquired before and one after therapy. These relative displacements, combined with knowledge of the exposure protocol, material properties, heat transfer, and measurement noise statistics, provide a natural framework for estimating the administered heating, and thereby therapy. The proposed method, termed displacement analysis, identifies the relative displacements using linearly independent displacement patterns, or modes, each induced by a particular time-varying heating applied during the exposure interval. These heating modes are themselves linearly independent. This relationship implies that a linear combination of displacement modes aligning the DU measurements is the response to an identical linear combination of heating modes, providing the heating estimate. Furthermore, the accuracy of coefficient estimates in this approximation is determined a priori, characterizing heating, thermal dose, and temperature estimates ...Continue Reading

References

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Jan 18, 2007·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Ajay AnandChristopher Hall
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May 3, 2008·Ultrasound in Medicine & Biology·Ajay Anand, Peter J Kaczkowski

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Citations

Mar 19, 2013·Ultrasound in Medicine & Biology·Moath M Al-QrainiGhanem F Oweis
Dec 5, 2014·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Prasanna HariharanMatthew R Myers

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