PMID: 3319639Jan 1, 1987Paper

Disposition and hypoglycaemic action of glipizide in diabetic patients given a single dose of nifedipine

European Journal of Clinical Pharmacology
A A ConnacherI H Stevenson

Abstract

Six well controlled Type 2 diabetics who had received glipizide therapy ranging from 5 mg to 30 mg daily for at least the previous 2 months were studied. On Days 1 and 15 nifedipine 20 mg or placebo respectively were given in a random crossover design after an overnight fast and with the morning dose of glipizide. Nifedipine did not influence the disposition of glipizide since there was no significant alteration in the maximum concentration, time to peak plasma concentration, elimination half-life or area under the curve. Neither did it have a major effect on plasma glucose or insulin although there was an early preprandial decrease in insulin level which reached significance at 1 h only (22.66 v 18.50 mIU/l).

References

Sep 1, 1977·The Journal of Clinical Endocrinology and Metabolism·H E LebovitzF L Lebovitz
Jan 1, 1985·European Journal of Clinical Pharmacology·L GroopF Fyhrqvist
Dec 1, 1970·Metabolism: Clinical and Experimental·A MarshallP H Wright
Jan 1, 1983·European Journal of Clinical Pharmacology·S Dean, M J Kendall
Jul 7, 1984·British Medical Journal·S K BhatnagarA R Al-Yusuf
Jul 4, 1981·British Medical Journal·S CharlesA E Lambert
Jan 1, 1980·Current Medical Research and Opinion·T Donnelly, A D Harrower
Nov 1, 1980·European Journal of Clinical Pharmacology·D GiuglianoM Varricchio

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