Disposition and metabolism of the bisphenol analogue, bisphenol S, in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans

Toxicology and Applied Pharmacology
Suramya WaidyanathaTimothy R Fennell

Abstract

With the removal of bisphenol A (BPA) from many consumer products, the potential use of alternatives such as bisphenol S (BPS) and its derivatives is causing some concerns. These studies investigated the comparative in vitro hepatic clearance and metabolism of BPS and derivatives and the disposition and metabolism of BPS in rats and mice following gavage and intravenous administration. The clearance of BPS and its derivatives was slower in human hepatocytes than in rodents. In male rats following gavage administration of 50, 150, and 500 mg/kg [14C]BPS the main route of excretion was via urine; the urinary excretion decreased (72 to 48%) and the fecal excretion increased (16 to 30%) with increasing dose. The disposition was similar in female rats and male and female mice following gavage administration. Radioactivity remaining in tissues at 72 h in both species and sexes was ≤2.4%. In bile duct cannulated rats 53% of a gavage dose was secreted in bile suggesting extensive enterohepatic recirculation of [14C]BPS. Following an intravenous dose in rats and mice, the pattern of excretion was similar to gavage. These data suggest that the dose excreted in feces folowing gavage administration is likely the absorbed dose. Urinary meta...Continue Reading

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Citations

May 22, 2019·Archives of Toxicology·Miguel A SogorbEugenio Vilanova
Jun 6, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Suramya WaidyanathaC Edwin Garner
Sep 29, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Suramya WaidyanathaTimothy R Fennell
Dec 14, 2021·The Science of the Total Environment·Weili MaoHangbiao Jin

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