PMID: 9635713Jul 4, 1998Paper

Disposition and tissue distribution of boron after infusion of borocaptate sodium in patients with malignant brain tumors

International Journal of Radiation Oncology, Biology, Physics
V HornF Tovarys

Abstract

In the frame of the Czech boron neutron capture therapy (BNCT) project, a clinical Phase I study of borocaptate sodium [Na2B12H11SH (BSH)] as the boron-10 delivery agent was performed to obtain data on disposition and tissue distribution of boron after an infusion of this compound, as well as to establish an optimal protocol for BNCT of malignant cerebral tumors. The kinetics of boron disposition after an infusion of borocaptate sodium (25 mg/kg body wt over the period of 1 h) was studied in a group of 10 patients with astrocytoma or glioblastoma of cerebral hemispheres using a modification of the Soloway-Messer colorimetric method. The boron content of tissues (tumor, healthy brain, dura mater, muscle, skin, and cranial bone) removed during the operation performed with latencies varying between 3 and 18 h was investigated by atomic emission spectrometry. Compartmental analysis of boron blood concentrations has shown that in the majority of patients (four males and three females), the concentration decline can be adequately described by a two-compartment pharmacokinetic model (i.e., by a biexponential relationship). The calculated half-lives of the initial (fast) phase of the concentration decline varied between 0.85 and 3.65 h...Continue Reading

References

Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L DewitD Gabel
Apr 1, 1972·Journal of Neuropathology and Experimental Neurology·A K AsburyW H Sweet
Jul 1, 1967·Journal of Medicinal Chemistry·A H SolowayM A Davis
Oct 1, 1994·Journal of Pharmacokinetics and Biopharmaceutics·T M LuddenL B Sheiner
Mar 30, 1994·International Journal of Radiation Oncology, Biology, Physics·D HaritzR Huiskamp
Apr 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·V GregoireH Bartelink
Dec 1, 1995·Biopharmaceutics & Drug Disposition·S C Mehta, D R Lu
Jan 1, 1996·Bulletin du cancer. Radiothérapie : journal de la Société française du cancer : organe de la société française de radiothérapie oncologique·D Gabel

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Citations

Feb 8, 2003·International Journal of Radiation Oncology, Biology, Physics·Wilko F A R VerbakelFinn Stecher-Rasmussen
May 17, 2003·Journal of Neuro-oncology·Katalin HideghétyDetlef Gabel
May 17, 2003·Journal of Neuro-oncology·Christopher R GibsonMelvin M Moeschberger
Jun 21, 2020·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Yoshitaka MatsumotoHideyuki Sakurai

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