PMID: 2589653Dec 1, 1989Paper

Disposition kinetics of ropivacaine in humans

Anesthesia and Analgesia
A LeeD B Scott


The pharmacokinetic characteristics of a new local anesthetic drug, ropivacaine, were determined after intravenous infusion of 50 mg of the hydrochloride salt into six healthy male volunteers. Results showed that the disposition of ropivacaine can be described by a biexponential function. Its blood clearance (0.72 +/- 0.16 L/min) is intermediate between that of mepivacaine and bupivacaine. Plasma binding averaged 94% +/- 1% and the volume of distribution at steady state based on blood drug concentration was 59 +/- 7 L. The terminal elimination half-life was 111 +/- 62 min.


Nov 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R HickeyS Ramamurthy
Nov 18, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A N SandlerD Muzyka
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May 1, 1991·Anaesthesia·F Reynolds
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Jan 10, 2002·Journal of Pharmaceutical Sciences·Patrick Poulin, Frank-Peter Theil
May 5, 2010·Neuroimaging Clinics of North America·John M MathisCharles H Cho
Jan 9, 2008·International Journal of Pediatric Otorhinolaryngology·Fatih OghanOzcan Ozturk
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Mar 24, 2005·Annals of Plastic Surgery·Despoina KakagiaGregory Tripsiannis
Aug 31, 2004·Anesthesia and Analgesia·Sachiko TodorokiKoji Sumikawa

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