PMID: 8583543Aug 1, 1995Paper

Disposition kinetics of tylosin tartrate administered intravenously and intramuscularly to normal and water-deprived camels

Journal of Veterinary Pharmacology and Therapeutics
G ZivR Yagil

Abstract

The disposition kinetics of tylosin tartrate administered intravenously (i.v.) at 10 mg/kg and intramuscularly (i.m.) at 20 mg/kg were studied in normal camels and in the same camels at the end of a 14 day water-deprivation period. After i.v. treatment, serum tylosin concentrations in the water-deprived camels were significantly higher, rate of drug elimination was slower, the volume of distribution was significantly smaller, and total body clearance was significantly slower than in the normal camels. On the other hand, serum drug concentrations were lower in the water deprived camels after i.m. dosing, the mean absorption time was significantly shorter and the i.m. availability was significantly smaller than in the normal camels. Water-deprivation was thought to cause reduced rate of tylosin elimination by the liver, as was shown for antipyrine--a drug which is eliminated from the body exclusively by the liver. Redistribution of tylosin in tissues concomitant with a greater proportion of drug in blood and extracellular fluid of water-deprived camels was suggested as a partial explanation for the higher serum drug levels seen after i.v. dosing. The low i.m. availability observed in the water-deprived camels implies that i.v. is...Continue Reading

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Citations

Sep 3, 2002·Research in Veterinary Science·C PratsB Pérez
Sep 1, 1996·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·B H AliA K Bashir
Oct 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·R GavrielliA Glickman
Nov 12, 2010·The Journal of Veterinary Medical Science·Eun-Young KimSeung-Chun Park
Jul 31, 2003·Journal of Veterinary Pharmacology and Therapeutics·K JanusZ Muszczynski
Nov 19, 2010·Journal of Veterinary Pharmacology and Therapeutics·S Modric, M Martinez
Nov 24, 1999·The Veterinary Journal·C R Short
Nov 2, 2019·Journal of Veterinary Pharmacology and Therapeutics·Sara T ElazabWalter H Hsu
Oct 26, 2018·BMC Veterinary Research·Lingli HuangZonghui Yuan

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