Disposition of a soluble chromate in the isolated perfused rat liver

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
H J WiegandH M Bolt

Abstract

The uptake of potassium dichromate in the isolated perfused rat liver was almost complete after one hour of perfusion. No significant sex differences in chromium distribution were observed. At the end of the experiments (one hour), about 60% of the applied Cr(VI) dose (312 micrograms Cr/liver) was located in the cytosol, 14% was in the mitochondria, 9% in the microsomal pellet and 2% was associated with the nuclei. Gel chromatography of the cytosol showed that most of the chromium was in fractions with an apparent molecular weight of 6000 Da and absorption maxima at 410 nm and 548 nm. Similar optical properties and molecular weight are characteristic of GSH-Cr complexes formed by reaction of Cr(VI) with GSH in vitro.

References

Jan 1, 1976·Methods in Cell Biology·P O Seglen
Jan 1, 1985·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·H J WiegandH M Bolt
Apr 1, 1985·Archives of Toxicology·H J WiegandH M Bolt
Jan 1, 1982·Toxicology·J AlexanderT Norseth
Nov 1, 1982·Acta Pharmacologica Et Toxicologica·T NorsethS Langård
Dec 1, 1950·The Journal of Clinical Investigation·S J GRAY, K STERLING

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Citations

Dec 1, 1989·Environmental Geochemistry and Health·P O'Brien, G Wang
Mar 26, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·P L AbreuA M Urbano
Jul 6, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Huoy-Rou ChangWei-Chang Tseng
May 13, 2006·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Richard M SedmanRobert Howd

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