PMID: 6540513May 1, 1984Paper

Disposition of ethanol and its effect on rectal temperature in morphine-dependent, morphine-abstinent and morphine-naive rats

Acta Pharmacologica Et Toxicologica
A W Jones

Abstract

Rats were treated chronically with twice daily injections of morphine hydrochloride in gradually increasing doses from 20 to 200 mg/kg for 22 consecutive days. Rats in a control group were injected with 0.9% NaCl. At 1 hour after the last injection of morphine (dependent state) and at 3 and 16 days after abrupt withdrawal (abstinent state) the animals were injected intraperitoneally with 2.0 g/kg ethanol. Blood ethanol concentrations (tail blood) and rectal temperatures were determined at 30-60 min. intervals for up to 7 hours. The absorption of ethanol was slower in rats treated with morphine and the time taken to reach the end of the blood concentration curve was increased. This implies a slower turnover of ethanol in morphine-dependent and abstinent rats. At 16 days after withdrawal, the blood ethanol profiles were the same as in control rats not exposed to morphine. Injection of morphine (200 mg/kg) intolerant animals caused a pronounced hyperthermia which lasted for about 4 hours. Ethanol treatment rapidly counteracted the rise in body temperature. Morphine abstinent rats showed a hypothermic response to ethanol. The altered disposition of ethanol in acute withdrawal may result from physiological disturbances such as impai...Continue Reading

References

Oct 26, 1979·European Journal of Pharmacology·J M KhannaA E Leblanc
Mar 1, 1979·Pharmacology, Biochemistry, and Behavior·R F MuchaM A Linseman
May 1, 1983·Acta Pharmacologica Et Toxicologica·H I ThiedenK Münster
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·V P DoleR F McGivern
Aug 1, 1982·The Journal of Nervous and Mental Disease·B J RounsavilleH D Kleber
Apr 1, 1980·Pharmacology, Biochemistry, and Behavior·R A Howd, G T Pryor
Jan 1, 1981·Progress in Neuro-psychopharmacology·R Numan, H Lal
May 21, 1963·Psychopharmacologia·W R MARTINF T PESCOR

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