Disposition of ipriflavone (TC-80) in rats and dogs

K YoshidaS Tanayama


Oral 14C-ipriflavone was absorbed by rats to give a maximum plasma 14C level at 1.5 h and a half-life of 5.8 h. In dogs, after po dosing, the plasma 14C peaked at 0.5 h, followed by gradual decline. The plasma of both animals contained mostly metabolites, with small amounts of unchanged ipriflavone. In rats, 14C was distributed widely in tissues, with relatively high concns. in the liver, kidney and gut. Distribution in rat thigh bone of unmetabolized ipriflavone was also demonstrated. 14C-Ipriflavone was eliminated mostly as metabolites within 48 and 72 h, respectively, in rats and dogs. Rats excreted more 14C in urine than in feces, whereas the reverse was noted in dogs. Biliary excretion and reabsorption of 14C were also obvious in both animals.


Sep 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S BenvenutiM L Brandi
Nov 1, 1994·Calcified Tissue International·S L ChengR Civitelli
Jan 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M L Brandi
Jan 1, 1992·Calcified Tissue International·K NotoyaM Kumegawa
Mar 17, 2001·Environmental Health Perspectives·P L Whitten, H B Patisaul
May 21, 2010·Clinical Pharmacokinetics·Neal M DaviesJaime A Yáñez
Jan 7, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Juliana Macedo DelarmelinaMaria do Carmo Pimentel Batitucci
Aug 1, 1997·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·D de AloysioF Bottiglioni
Oct 1, 1992·Bone and Mineral·M L Brandi

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