Disposition of lead (Pb) in saliva and blood of Sprague-Dawley rats following a single or repeated oral exposure to Pb-acetate

Toxicology
Charles TimchalkW Yantasee

Abstract

Biological monitoring for lead (Pb) is usually based upon a determination of blood Pb concentration; however, saliva has been suggested as a non-invasive biological matrix for assessing exposure. To further evaluate the potential utility of saliva for biomonitoring, the disposition of Pb was evaluated in whole blood (WB), red blood cells (RBC), plasma, parotid gland, bone, and saliva following either a single oral dose of 100mg Pb-acetate/kg body weight in rats or approximately 1-week after 5 sequential daily oral gavage doses of 1, 10, or 100mg Pb-acetate/kg/day. Saliva volume, pH, total saliva protein, and alpha-amylase activity were also determined. At specified times post-dosing groups of animals were anesthetized and administered pilocarpine to induce salivation. Saliva was collected, the animals were humanely sacrificed, and tissue samples were likewise collected, weighed, and processed for Pb analysis. Following a single dose exposure to Pb-acetate, Pb was detectable in all samples by 30 min post-dosing. For both the single and repeated dose treatments the concentration of Pb was highest in WB and RBC relative to plasma and saliva. However, the Pb rapidly redistributed (within 5-days post-treatment) from the blood into t...Continue Reading

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Citations

Aug 3, 2006·Environmental Health Perspectives·Dennis Paustenbach, David Galbraith
Sep 4, 2012·Clinics in Laboratory Medicine·Donald L Frederick
Jun 16, 2015·Frontiers in Pharmacology·Charles TimchalkJordan N Smith
Jul 27, 2014·Environmental Science and Pollution Research International·Olga V SavchenkoYuri S Khotimchenko
Aug 26, 2009·Anesthesiology Clinics·Mary Ellen McCann, Sulpicio G Soriano
Jan 24, 2019·International Journal of Environmental Research and Public Health·Milena AndjelkovicZorica Bulat
Oct 27, 2020·Environmental Science and Pollution Research International·Géssica de Oliveira LopesRafael Rodrigues Lima
Oct 3, 2021·Environmental Science and Pollution Research International·Lodinikki Lemoy DavisRafael Rodrigues Lima

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