Disposition of levetiracetam in healthy adult horses

Journal of Veterinary Pharmacology and Therapeutics
F B CesarA A Wooldridge

Abstract

Nine horses received 20 mg/kg of intravenous (LEVIV ); 30 mg/kg of intragastric, crushed immediate release (LEVCIR ); and 30 mg/kg of intragastric, crushed extended release (LEVCER ) levetiracetam, in a three-way randomized crossover design. Crushed tablets were dissolved in water and administered by nasogastric tube. Serum samples were collected over 48 hr, and levetiracetam concentrations were determined by immunoassay. Mean ± SD peak concentrations for LEVCIR and LEVCER were 50.72 ± 10.60 and 53.58 ± 15.94 μg/ml, respectively. The y-intercept for IV administration was 64.54 ± 24.99 μg/ml. The terminal half-life was 6.38 ± 1.97, 7.07 ± 1.93 and 6.22 ± 1.35 hr for LEVCIR , LEVCER, and LEVIV , respectively. Volume of distribution at steady-state was 630 ± 73.4 ml/kg. Total body clearance after IV administration was 74.40 ± 19.20 ml kg-1  hr-1 . Bioavailability was 96 ± 10, and 98 ± 13% for LEVCIR and LEVCER , respectively. A single dose of Levetiracetam (LEV) was well tolerated. Based on this study, a recommended dosing regimen of intravenous or oral LEV of 32 mg/kg every 12 hr is likely to achieve and maintain plasma concentrations within the therapeutic range suggested for humans, with optimal kinetics throughout the dosing i...Continue Reading

References

Sep 1, 1992·Journal of Veterinary Pharmacology and Therapeutics·J M Reimer, R W Sweeney
Nov 10, 1992·European Journal of Pharmacology·A J GowerE Wülfert
Jun 14, 2003·The Neurologist·Carl W Bazil
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Berkley A LynchBruno Fuks
Aug 11, 2004·Clinical Pharmacokinetics·Philip N Patsalos
Jul 23, 2005·Australian Veterinary Journal·S L Raidal, S Edwards
May 1, 2007·The Veterinary Journal·Holger A VolkKate E Chandler
Jul 13, 2007·Neurology·S F BerkovicUNKNOWN Levetiracetam N01057 Study Group
Aug 19, 2007·Seizure : the Journal of the British Epilepsy Association·Deron V SharpeGerald M Fenichel
May 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·E E PattersonI E Leppik
Sep 16, 2010·Journal of Veterinary Pharmacology and Therapeutics·R L TerryB Driessen
Sep 2, 2011·American Journal of Veterinary Research·Michelle Brogan CarnesDawn M Boothe
Jun 28, 2013·American Journal of Veterinary Research·Kathleen R MullenThomas J Divers
Jul 31, 2013·The Veterinary Clinics of North America. Small Animal Practice·Karen R Muñana
Aug 21, 2015·Journal of Veterinary Internal Medicine·M J Beasley, D M Boothe

❮ Previous
Next ❯

Citations

Dec 2, 2017·Equine Veterinary Journal·K D MacDonaldS Giguère

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Veterinary Pharmacology and Therapeutics
C M SteelB G Charles
Journal of Veterinary Pharmacology and Therapeutics
J O ErrecaldeM S Mulders
Journal of Veterinary Pharmacology and Therapeutics
M H CourtM Clark
© 2022 Meta ULC. All rights reserved