Abstract
Solvent Green 3 (SG), a model poorly water-soluble compound, was orally administered to rats with soybean oil emulsion or the Self-microemulsifying drug delivery system (SMEDDS) composed of Gelucire44/14. The bioavailability of SG after oral administration with SMEDDS was 1.7-fold higher than that with soybean oil emulsion. The intestinal absorption of lipid-based formulations themselves was evaluated by the in situ closed loop method. The effect of lipase and bile salt on their absorption was also evaluated. SMEDDS itself was rapidly absorbed in the intestine even in the absence of lipase and bile salt, and the absorption was increased by the addition of lipase and bile salt. On the other hand, no soybean oil emulsion was absorbed in the absence of lipase and bile salt. However, mixed micelle prepared from emulsion by incubating soybean oil emulsion with lipase and bile salt was rapidly absorbed through the intestine. Without lipase and bile salt, SG was not absorbed after administration with soybean oil emulsion. Therefore, we concluded that the degradation of soybean oil emulsion was needed for SG to be absorbed through the intestine. Furthermore, we investigated the intestinal absorption of SG after oral administration to r...Continue Reading
References
May 27, 1976·Biochimica Et Biophysica Acta·C A Arreaza-PlazaM A Otayek
Apr 1, 1987·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·G B McDonald, M Weidman
Nov 1, 1993·The Journal of Pharmacy and Pharmacology·T NishihataM Ishizaka
Mar 1, 1994·Journal of Pharmaceutical Sciences·J M KovarikK Kutz
Apr 1, 1996·Journal of Pharmaceutical Sciences·C J PorterW N Charman
Feb 1, 1996·Pharmaceutical Research·P P ConstantinidesA B Owen
Mar 31, 1998·Journal of Pharmaceutical Sciences·D J HaussJ J Keirns
Sep 2, 1998·Transplantation Proceedings·F GaspariG Remuzzi
Dec 2, 1999·Atherosclerosis·M M Hussain
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C Leuner, J Dressman
Jan 17, 2004·International Journal of Pharmaceutics·P Chris de SmidtIñaki F Trocóniz
Mar 23, 2004·Pharmaceutical Research·Shicheng YangSimon Benita
Apr 10, 2004·International Journal of Pharmaceutics·Bok Ki KangSun Hang Cho
Citations
Jul 27, 2012·Therapeutic Delivery·Monica VialpandoGuy Van den Mooter
Apr 20, 2013·International Journal of Pharmaceutics·René HolmHuiling Mu
May 20, 2009·Pharmaceutical Research·Sylvie FernandezVincent Jannin
Dec 10, 2008·Drug Development and Industrial Pharmacy·Celine DitnerMartin Kuentz
Aug 9, 2007·Expert Opinion on Drug Delivery·Alfred Fahr, Xiangli Liu
Sep 20, 2007·Journal of Pharmaceutical Sciences·Weilun KeYuanying Pei
Jan 10, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Takayuki YoshidaKazuhiro Sako
Apr 3, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·René HolmAnette Müllertz
Jan 25, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·René HolmJette Jacobsen
Nov 18, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Angel TanClive A Prestidge
Jun 24, 2008·Biochimica Et Biophysica Acta·Sylvie FernandezVincent Jannin
Mar 21, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Rong QiQiang Zhang
Dec 25, 2007·Advanced Drug Delivery Reviews·Christopher J H PorterWilliam N Charman
Dec 19, 2015·International Journal of Pharmaceutical Investigation·Ramprasad ChintalapudiG Ganesh Manohar
Jun 27, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·René HolmAnette Müllertz
Jul 31, 2016·International Journal of Pharmaceutics·Qiao XingHaiyan Hu
May 12, 2018·Lipids in Health and Disease·Jyothshna Devi KatamreddyJaya Preethi Peesa
Jan 30, 2010·Critical Reviews in Food Science and Nutrition·R ErgunR W Hartel
Oct 2, 2013·Archives of Pharmacal Research·Kazunori IwanagaMasawo Kakemi
Jul 6, 2019·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Maria Høtoft MichaelsenAnette Müllertz
Mar 12, 2021·Expert Opinion on Drug Metabolism & Toxicology·Teruo MurakamiNicholas Bodor
Feb 5, 2008·International Journal of Pharmaceutics·Ping ZhangJie Xu
Jul 6, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Alexandra-Roxana IlieRené Holm
Mar 31, 2019·Advanced Drug Delivery Reviews·Sawsan AmaraFrédéric Carrière