Disposition of oral telithromycin in foals and in vitro activity of the drug against macrolide-susceptible and macrolide-resistant Rhodococcus equi isolates

Journal of Veterinary Pharmacology and Therapeutics
L H JavsicasA Womble

Abstract

The objectives of this study were to determine the serum and pulmonary disposition of telithromycin in foals and to determine the minimum inhibitory concentration (MIC) of telithromycin against macrolide-susceptible and macrolide-resistant Rhodococcus equi isolates. A single dose of telithromycin (15 mg/kg of body weight) was administered to six healthy 6-10-week-old foals by the intragastric route. Activity of telithromycin was measured in serum, pulmonary epithelial lining fluid (PELF), and bronchoalveolar lavage (BAL) cells using a microbiological assay. The broth macrodilution method was used to determine the MIC of telithromycin, azithromycin, clarithromycin and erythromycin against R. equi. Following intragastric administration, mean +/- SD time to peak serum telithromycin activity (T(max)) was 1.75 +/- 0.76 h, maximum serum activity (C(max)) was 1.43 +/- 0.37 microg/mL, and terminal half-life (t(1/2)) was 3.81 +/- 0.40 h. Telithromycin activity, 4 h postadministration was significantly higher in BAL cells (50.9 +/- 14.5 microg/mL) than in PELF (5.07 +/- 2.64 microg/mL), and plasma (0.84 +/- 0.25 microg/mL). The MIC(90) of telithromycin for macrolide-resistant R. equi isolates (8 microg/mL) was significantly higher than t...Continue Reading

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Citations

Oct 23, 2012·Journal of Veterinary Pharmacology and Therapeutics·N Villarino, T Martín-Jiménez
Jan 21, 2015·The Veterinary Clinics of North America. Equine Practice·Sarah M Reuss, Noah D Cohen
Mar 21, 2017·Journal of Veterinary Pharmacology and Therapeutics·S BerlinW Siegmund
Mar 16, 2021·Journal of Veterinary Pharmacology and Therapeutics·Hannah R LeventhalJennifer L Davis

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