PMID: 8583362Aug 1, 1995Paper

Disposition of polaprezinc (zinc L-carnosine complex) in rat gastrointestinal tract and effect of cimetidine on its adhesion to gastric tissues

The Journal of Pharmacy and Pharmacology
S FurutaH Sano

Abstract

The disposition of polaprezinc in the rat gastrointestinal tract was studied by a double tracer method using [14C]- and [65Zn]polaprezinc. At 0.5 h after oral administration of [14C]-,[65Zn]polaprezinc to rats, the 14C-radioactivity in the gastric contents was comparable with the 65Zn-radioactivity. However, a significant difference was observed in the time course of changes in gastric contents between 14C- and 65Zn-radioactivity over 1 h after administration, indicating that polaprezinc existed in complex form at 0.5 h after administration and was dissociated to L-carnosine and zinc in the gastrointestinal tract as a function of time. The adhesion of zinc to stomach mucosa after oral administration of polaprezinc to rats was significantly increased by treatment with cimetidine. These results suggest that the adhesion of zinc to gastric tissues is increased by inhibiting the dissociation of polaprezinc, and that H2-receptor antagonists, such as cimetidine, may increase anti-ulcer effects of polaprezinc.

References

Dec 1, 1975·British Journal of Clinical Pharmacology·W L BurlandJ H Wyllie
May 12, 1975·Analytical Biochemistry·A Viotti, R Nucca
May 1, 1990·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·M SeikiS Okabe
Oct 1, 1986·Journal of Pharmacobio-dynamics·T FunakiN Kaneniwa
Nov 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S FurutaH Sano
Feb 1, 1962·The Journal of Nutrition·C S Marcus, F W Lengemann

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Citations

Mar 7, 2000·Journal of Pharmaceutical and Biomedical Analysis·S FurutaH Sano
Jun 27, 2019·Nutrients·Enza D'AuriaGianVincenzo Zuccotti
Nov 2, 2021·Experimental and Therapeutic Medicine·Mingru LiZhaoyang Liu

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