PMID: 7467406Mar 1, 1980

Disposition of pranolium chloride in small mammals

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
A BarrowR F Palmer

Abstract

The disposition of [14C]pranolium chloride, a dimethyl quaternary derivative of propranolol, has been studied in rats, mice and hamsters after oral parenteral dosage. 2. Elimination of 14C occurred largely via the kidneys after parenteral dosage, but biliary excretion was significant. Pranolium chloride was excreted unchanged and as a conjugate, and was also metabolized to 1-naphthol which was conjugated. 3. The radiolabel was localized in the liver, kidneys, heart, lungs and gastro-intestinal tract of the rat, but did not pass the placental or blood-brain barriers to any appreciable extent. Unchanged pranolium chloride was localized in rat cardiac tissue for at least 6 h after i.v. dosage. 4. Pranolium chloride was poorly and variably absorbed from the gastro-intestinal tract of animals. Peak plasma levels occurred between 10 min and 1 h. The absorption of the pranolium cation was marginally increased after prolonged fasting, but was not affected by the presence of alternative anions.

References

Jan 15, 1977·Biochemical Pharmacology·K Turnheim, F Lauterbach
Oct 6, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·K Turnheim, F Lauterbach
Oct 1, 1974·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·I D CapelR T Williams
Feb 1, 1973·Journal of Pharmaceutical Sciences·M Gibaldi, B Grundhofer

Citations

Apr 2, 2003·European Journal of Medicinal Chemistry·Yuan H ZhaoI Cooper

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