PMID: 6101158Sep 1, 1981Paper

Disposition of sulfadimethoxine in cattle: inclusion of protein binding factors in a pharmacokinetic model

Journal of Pharmaceutical Sciences
D W BourneR F Bevill


Sulfadimethoxine was administered intravenously and orally to four cattle, and plasma and urine samples were collected at various times postdose. Modeling these data with a linear pharmacokinetic model gave unsatisfactory fits, and the data were subsequently fitted to a one-compartment model with saturable protein binding. The saturable protein binding model included the usual linear excretion and elimination processes as well as protein binding parameters. The values obtained in vivo for the binding constant, 5.01 x 10(4) M-1, and the total protein concentration, 7.89 x 10(-4) M, compared favorably with previously reported in vitro values. These results indicate that protein binding can be successfully included in a pharmacokinetic model.


Feb 24, 2001·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·N Furusawa
Mar 10, 2010·Journal of Pharmaceutical Sciences·Marilyn N MartinezSanja Modric
Dec 1, 1990·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C M MichelJ M O'Connor
Aug 13, 2011·Journal of Veterinary Pharmacology and Therapeutics·O A ChiesaJ von Bredow
Aug 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L HakimE J Triggs
Jul 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L HakimE J Triggs
Mar 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M G BarronM O James
Jul 15, 2015·Environmental Geochemistry and Health·Jinrong QiuZhencheng Xu
Jul 18, 2006·British Journal of Clinical Pharmacology·N WidmerT Buclin
May 31, 2001·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·N Furusawa
Oct 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·R F BevillD W Bourne

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