PMID: 3212941Jan 1, 1988Paper

Disposition of sulfadimethoxine in the lobster (Homarus americanus)

Veterinary and Human Toxicology
M O James, M G Barron

Abstract

The long-acting sulfonamide antibacterial, sulfadimethoxine, has the potential for use in pen-held lobsters, Homarus americanus for treatment of gaffkemia. We evaluated the disposition of sulfadimethoxine after intrapericardial, oral or multiple oral administration of unlabelled or radiolabelled sulfadimethoxine (42 mg/kg) to 500 g lobsters. Elimination of parent sulfadimethoxine from hemolymph was very slow compared with elimination of the drug from blood of vertebrate species; the beta phase half-life was 77 hr in lobster as opposed to 7-40 hr in several vertebrate species. The pharmacokinetics of sulfadimethoxine after intrapericardial administration were linear up to 55 mg/kg, and binding of sulfadimethoxine to hemolymph proteins was constant over the range 14-200 micrograms/ml. During the first week after dosing, concentrations of sulfadimethoxine and metabolites (total radioactivity) were similar in all non-excretory tissues, such that muscle, shell and hemolymph contained the largest percentage of the administered dose. By 2 weeks and later, hepatopancreas and digestive tract contained the highest concentration and percentage of the dose, by total radioactivity. Part of the dose of sulfadimethoxine was excreted unchanged...Continue Reading

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