PMID: 16509024Mar 3, 2006Paper

Disposition of two oral formulations of cyclosporine in pediatric patients receiving hematopoietic stem cell transplants

Pharmacotherapy
L Lee DupuisE Fred Saunders

Abstract

To compare the disposition of cyclosporine after the administration of two oral formulations to children undergoing hematopoietic stem cell transplantation, and to evaluate the relationship between whole blood cyclosporine concentrations during the dosing interval and the area under the whole blood concentration-time curve. Prospective, descriptive, crossover study.Setting. Hematopoietic stem cell transplantation unit in a tertiary-quaternary university-affiliated pediatric hospital. Twenty-four pediatric patients aged 0.5-16.9 years undergoing allogeneic hematopoietic stem cell transplantation. The modified oral formulation of cyclosporine was given on the first day (divided as two doses), and a single identical dose of the original oral formulation was given on the morning of the second day. Blood samples were obtained at 0, 0.5, 1.25, 2, 4, 6, 9, and 12 hours after the morning dose from the lumen of the central venous catheter not previously used for intravenous cyclosporine administration. Cyclosporine concentration-time data were analyzed by using noncompartmental methods. Mean +/- SD maximum concentrations were significantly higher after administration of the modified form than after administration of the original form (5...Continue Reading

References

Nov 1, 1992·Clinical & Experimental Metastasis·N HunterL Milas
Apr 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A BökenkampJ Brodehl
Jun 1, 1997·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S C KabasakulG Clark
Feb 9, 2000·Journal of the American Society of Nephrology : JASN·Elias David-NetoLuis Estevan Ianhez
Nov 30, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H U Meier-KriescheR J Portman
May 17, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J LemireV Reznik
May 23, 2002·Transplantation·Björn NashanEric Thervet
May 23, 2002·Transplantation·Gary LevyUNKNOWN Consensus on Neoral C(2): Expert Review in Transplantation (CONCERT) Group
Oct 2, 2003·Bone Marrow Transplantation·J-E JohanssonT Ekman
Oct 1, 2002·Paediatrics & Child Health·Guido Filler, Janusz Feber

❮ Previous
Next ❯

Citations

May 22, 2008·British Journal of Clinical Pharmacology·A J WillemzeJ M Vossen
Oct 5, 2013·AAPS PharmSciTech·Jiraphong SuksiriworapongDoungdaw Chantasart

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.