PMID: 6103631May 1, 1980Paper

Disposition pharmacokinetics of lorazepam in the rabbit

Acta Pharmacologica Et Toxicologica
F Nielsen-Kudsk, P Jakobsen

Abstract

The disposition pharmacokinetics of the sedative and anxiolytic drug lorazepam were investigated in 8 rabbits in relation to intravenous bolus injection of 0.3 or 0.6 mg of the compound. Lorazepam showed distinct linear two-compartment characteristics with a mean biological half-life (t 1/2 beta) of only 73.7 min. +/- 17.3 S.D. The mean half-life of the alpha phase of distribution was 18.4 min. +/- 4.7 S.D. The mean apparent steady state volume of distribution was 1.64 1 kg-1 +/- 0.27 S.D., Vc-mean was 1.11 1 kg-1 +/- 0.24 S.D. and Vdarea 2.26 1 kg-1 +/- 0.16 S.D. The calculated apparent volume of the peripheral compartment amounted to 0.53 1 kg-1 +/- 0.28 S.D. Compared to human data the distribution of lorazepam takes place somewhat slower in an about two-times as great apparent volume of distribution, while the disposition of the compound proceeds with an about 20 times as high rate.

References

Sep 1, 1976·Clinical Pharmacology and Therapeutics·D J GreenblattH W Ruelius
Feb 1, 1977·Clinical Pharmacology and Therapeutics·D J GreenblattH W Ruelius
Aug 1, 1977·Journal of Clinical Pharmacology·D J GreenblattH W Ruelius
Jan 1, 1979·Journal of Pharmaceutical Sciences·D J GreenblattE Woo
Jul 1, 1976·Journal of Pharmaceutical Sciences·A J Sedman, J G Wagner
Sep 1, 1971·Journal of Pharmaceutical Sciences·M GibaldiS Feldman

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Citations

Nov 7, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K WaltonA G Renwick

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