Disproportionately elevated proinsulin levels precede the onset of insulin-dependent diabetes mellitus in siblings with low first phase insulin responses. The Childhood Diabetes in Finland Study Group

The Journal of Clinical Endocrinology and Metabolism
M E RøderC Binder

Abstract

The objective of this study was to test whether levels of proinsulin immunoreactivity (PIM) relative to those of insulin immunoreactivity (IRI) or C-peptide are changed and related to subclinical beta-cell dysfunction in siblings of insulin-dependent diabetes mellitus (IDDM) patients. Twenty-three siblings, previously found positive for islet cell antibodies and/or insulin autoantibodies, were divided into 2 groups according to their first phase insulin response (FPIR) to i.v. glucose tolerance tests (IVGTTs) sequentially performed during an observation period of 2 yr. Eleven siblings had diminished FPIR on at least 1 occasion (group 1), whereas 12 siblings had a normal FPIR on all occasions studied (group 2). All underwent a further IVGTT (0.5 g glucose/kg BW), and serum samples were taken at 0, 1, 3, 6, 10, 20, 30, 40, 50, and 60 min. The 2 groups had comparable median age, female/male ratio, weight, height, fasting blood glucose, immunoreactive insulin, C-peptide, and insulin autoantibodies levels, but group 1 had significantly higher islet cell antibodies levels. Fasting median PIM/IRI and PIM/C-peptide ratios were 2- to 3-fold higher in group 1 [10.5% (range, 1.8-93.8%) vs. 5.2% (range, 1.9-14.3%) and 3.3% (range, 0.4-23.1...Continue Reading

Citations

Jul 7, 1999·The Journal of Clinical Investigation·K HostensD G Pipeleers
Jan 12, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·A SchölinUNKNOWN Diabetes Incidence Study Group in Sweden (DISS)
Sep 18, 2013·Diabetes, Obesity & Metabolism·C Evans-MolinaR G Mirmira
Jul 5, 2011·Biochemical and Biophysical Research Communications·Jie Wang, Kwame Osei
Sep 14, 2001·Best Practice & Research. Clinical Endocrinology & Metabolism·F K GorusUNKNOWN Belgian Diabetes Registry
Mar 19, 2009·Clinical and Experimental Immunology·S I ManneringL C Harrison
Dec 3, 2016·PloS One·Annelien Van DalemUNKNOWN Belgian Diabetes Registry
Feb 10, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A F ReisA R Chacra
Jul 31, 2018·Expert Review of Endocrinology & Metabolism·Michael E Røder

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.