Disrupted brain connectivity networks in acute ischemic stroke patients

Brain Imaging and Behavior
Yifei ZhuHaiqing Yang

Abstract

Neuroimaging studies have shown that local brain lesions could result in abnormal information transfer far from the lesion site in acute ischemic stroke (AIS) patients; yet, little is known about alternations of the topological organization of whole-brain networks in AIS. By using resting state functional magnetic resonance imaging (MRI) and graph theory analysis, we systematically investigated the topological properties of the functional brain networks of 28 healthy controls (HC, age: 56.9 ± 0.45 years) and 29 AIS (age: 57.6 ± 0.21 years) with proximal anterior circulation occlusion within 12 h of symptom onset. In our results, both the AIS and HC groups exhibited small-world network organization, suggesting a functional balance between local specialization and global integration. However, compared with the HC, the AIS patients had a lower shortest path length and higher global efficiency, indicating a tendency of randomization in patients' functional brain networks. The AIS patients had an increased nodal degree in the precuneus (PCUN), middle frontal gyrus (MFG), medial part of the superior frontal gyrus (SFGmed), orbital part of the middle frontal gyrus, and the opercular part of the inferior frontal gyrus, and increased no...Continue Reading

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Citations

Aug 8, 2018·Neuroscience Bulletin·Shengxiang LiangBaoci Shan
Apr 21, 2019·Human Brain Mapping·Yating LvJinhui Wang
Nov 23, 2019·Journal of Speech, Language, and Hearing Research : JSLHR·Swathi KiranJeffrey P Johnson
Aug 30, 2019·Stroke; a Journal of Cerebral Circulation·Michael Brainin
Nov 20, 2019·Stroke; a Journal of Cerebral Circulation·Hugo P AbenUNKNOWN PROCRAS Study Group
Jul 25, 2020·Brain Imaging and Behavior·Mengye ShiLiping Wang
Apr 20, 2019·Frontiers in Neurology·Swathi Kiran, Cynthia K Thompson
Mar 4, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Huiyou ChenYu-Chen Chen
May 5, 2021·Stroke; a Journal of Cerebral Circulation·Laura C C van MeenenJonathan M Coutinho
Jul 21, 2021·Stroke; a Journal of Cerebral Circulation·Gerard R HallTracy D Farr
Jul 6, 2021·Brain Communications·Dan D JobsonRajesh N Kalaria

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