Disrupted brain functional networks in drug-naïve children with attention deficit hyperactivity disorder assessed using graph theory analysis

Human Brain Mapping
Ying ChenQiyong Gong

Abstract

Neuroimaging studies have revealed functional brain network abnormalities in attention deficit hyperactivity disorder (ADHD), but the results have been inconsistent, potentially related to confounding medication effects. Furthermore, specific topological alterations in functional networks and their role in behavioral inhibition dysfunction remain to be established. Resting-state functional magnetic resonance imaging was performed on 51 drug-naïve children with ADHD and 55 age-matched healthy controls. Brain functional networks were constructed by thresholding the partial correlation matrices of 90 brain regions, and graph theory was used to analyze network topological properties. The Stroop test was used to assess cognitive inhibitory abilities. Nonparametric permutation tests were used to compare the topological architectures in the two groups. Compared with healthy subjects, brain networks in ADHD patients demonstrated altered topological characteristics, including lower global (FDR q = 0.01) and local efficiency (p = 0.032, uncorrected) and a longer path length (FDR q = 0.01). Lower nodal efficiencies were found in the left inferior frontal gyrus and anterior cingulate cortex in the ADHD group (FDR both q < 0.05). Altered gl...Continue Reading

References

Jun 12, 1998·Nature·D J Watts, S H Strogatz
May 29, 2000·Trends in Cognitive Sciences·G BushM I Posner
Mar 22, 2001·Nature·S H Strogatz
Feb 28, 2002·Behavioural Brain Research·Joseph A SergeantJaap Oosterlaan
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Nov 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Diane Swick, And U Turken
Mar 31, 2004·Trends in Cognitive Sciences·Adam R AronRussell A Poldrack
Sep 8, 2004·Trends in Cognitive Sciences·Olaf SpornsClaus C Hilgetag
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sophie AchardEd Bullmore
Jun 2, 2007·The American Journal of Psychiatry·Guilherme PolanczykLuis Augusto Rohde
Nov 22, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Kerstin KonradBeate Herpertz-Dahlmann
Feb 27, 2008·Brain : a Journal of Neurology·Yong LiuTianzi Jiang
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yong HeAlan Evans
Jul 5, 2008·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Sabine C HerpertzBeate Herpertz-Dahlmann
Oct 2, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·Mani N Pavuluri, John A Sweeney
Oct 7, 2008·Neuroscience and Biobehavioral Reviews·Christopher D ChambersMark A Bellgrove
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Jun 12, 2009·Journal of Community Health·Amy L ToblerMildred M Maldonado-Molina
Dec 24, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Simona SpinelliStewart H Mostofsky
Mar 20, 2012·Clinical EEG and Neuroscience·Mehran AhmadlouAmir Adeli
Jun 5, 2012·Journal of Attention Disorders·Nenad VasicGeorg Grön
Sep 18, 2012·The American Journal of Psychiatry·Samuele CorteseF Xavier Castellanos
Jan 15, 2013·Neuroscience and Biobehavioral Reviews·Philip Gerard Gasquoine
May 30, 2013·Journal of Abnormal Psychology·Jesse C BledsoeSteven R Pliszka
Jun 12, 2013·Biological Psychiatry·Charlotte NymbergUNKNOWN IMAGEN Consortium
Nov 23, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Tara McAuleyRussell Schachar
Apr 8, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yuanyuan LiQiyong Gong
Apr 18, 2014·Expert Review of Neurotherapeutics·Katya RubiaHelen Brinson

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