Disrupted functional connectivity in primary progressive apraxia of speech

NeuroImage. Clinical
Hugo BothaDavid T Jones

Abstract

Apraxia of speech is a motor speech disorder thought to result from impaired planning or programming of articulatory movements. It can be the initial or only manifestation of a degenerative disease, termed primary progressive apraxia of speech (PPAOS). The aim of this study was to use task-free functional magnetic resonance imaging (fMRI) to assess large-scale brain network pathophysiology in PPAOS. Twenty-two PPAOS participants were identified from a prospective cohort of degenerative speech and language disorders patients. All participants had a comprehensive, standardized evaluation including an evaluation by a speech-language pathologist, examination by a behavioral neurologist and a multimodal imaging protocol which included a task-free fMRI sequence. PPAOS participants were age and sex matched to amyloid-negative, cognitively normal participants with a 1:2 ratio. We chose a set of hypothesis driven, predefined intrinsic connectivity networks (ICNs) from a large, out of sample independent component analysis and then used them to initialize a spatiotemporal dual regression to estimate participant level connectivity within these ICNs. Specifically, we evaluated connectivity within the speech and language, face and hand senso...Continue Reading

Citations

Aug 14, 2020·Journal of Speech, Language, and Hearing Research : JSLHR·Kristen M AllisonJordan R Green
Sep 4, 2020·NeuroImage·Vincent van de VenIngrid Christoffels
Jan 26, 2021·Journal of Communication Disorders·Helena HybbinetteEllika Schalling
Mar 16, 2021·American Journal of Speech-language Pathology·Heather M ClarkKeith A Josephs
Jul 6, 2021·Aphasiology·Joseph R DuffyKeith A Josephs
Jul 23, 2021·Journal of the International Neuropsychological Society : JINS·Angelina J PolsinelliRene L Utianski
Aug 7, 2021·Clinical Linguistics & Phonetics·Liziane BouvierVincent Martel-Sauvageau

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Methods Mentioned

BETA
SMA
SMAs

Software Mentioned

Statistical Parametric Mapping ( SPM12 )
3dDespike
SPM12
Analysis of Functional NeuroImages ( AFNI )
DIVA
AlphaSim Data Analysis Toolkit ( RESTplus )
TF
R
MATLAB
AFNI

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