Disrupted local neural activity and functional connectivity in subjective tinnitus patients: evidence from resting-state fMRI study

Neuroradiology
Qi HanJian Wang

Abstract

The study aimed to investigate the abnormal alterations of both the intra-regional brain activity and inter-regional functional connectivity (FC) in patients with subjective tinnitus (ST) using resting-state functional MRI (rs-fMRI) methods. Twenty-five ST patients and 25 normal controls (NCs) were included and underwent resting-state functional magnetic resonance imaging scans. ReHo, fALFF, and seed-based FC were calculated and compared between ST patients and NCs. Meanwhile, correlation analyses were calculated between altered connectivity and clinical data in ST patients. Compared with NCs, ST patients exhibited increased ReHo and fALFF values in the right middle temporal gyrus (MTG), and the ReHo values were also increased in the right cuneus. In contrast, decreased ReHo values in ST patients were observed in the right middle frontal gyrus (MFG) and left cerebellar anterior lobe. Considering these brain areas with altered ReHo and fALFF clusters as seeds, the right MTG (ReHo) exhibited decreased connectivity with the right MFG, lingual gyrus, and left cerebellar posterior lobe, besides, the right cuneus showed decreased connectivity with the right MTG. In ST patients, the decreased FC between the right MTG (ReHo) and the ri...Continue Reading

References

Feb 1, 1996·Archives of Otolaryngology--head & Neck Surgery·C W NewmanJ B Spitzer
Aug 19, 1999·Hearing Research·F MirzA Gjedde
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Apr 28, 2004·NeuroImage·Yufeng ZangLixia Tian
Oct 12, 2004·Trends in Neurosciences·Jos J Eggermont, Larry E Roberts
Apr 23, 2005·Human Brain Mapping·Augusto PetacchiJames M Bower
Aug 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Seiki KonishiYasushi Miyashita
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·D MantiniM Corbetta
Apr 15, 2009·Hearing Research·Peyman AdjamianDeborah A Hall
Sep 22, 2009·Brain Research·Lawrence M ParsonsJames M Bower
Jan 14, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mohammad FarhadiGholamreza Raeisali
Jul 31, 2010·The American Journal of Medicine·Josef ShargorodskyWildon R Farwell
Jun 17, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jessica R Andrews-Hanna
Jan 6, 2012·BMC Neuroscience·Harold BurtonJay F Piccirillo
Mar 1, 2012·Neuron·Giuliano IurilliPaolo Medini
Mar 27, 2012·Hearing Research·Dennis GolmBirgit Kröner-Herwig
Feb 19, 2013·Hearing Research·Carol A BauerThomas J Brozoski
Jul 6, 2013·Lancet·David BaguleyDeborah Hall
Jul 31, 2013·Hearing Research·Fatima T Husain, Sara A Schmidt
Aug 21, 2013·Lancet Neurology·Berthold LangguthDirk De Ridder
Jan 21, 2014·Trends in Cognitive Sciences·Adam R AronRussell A Poldrack
Feb 6, 2014·PloS One·Martin SchecklmannUNKNOWN TRI Database Study Group
Mar 14, 2014·Journal of the American Academy of Audiology·James A HenryRichard J Salvi
Oct 3, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·David E TunkelElizabeth J Whamond
Oct 4, 2014·Frontiers in Neurology·Sarah H HayesRichard J Salvi
May 4, 2015·European Journal of Radiology·Jian ZhangGao-Jun Teng
Sep 17, 2015·Nature Reviews. Neuroscience·Ana Belén ElgoyhenSven Vanneste
Nov 12, 2015·BioMed Research International·Kathryn FackrellMagdalena Sereda
Apr 15, 2016·Neuroinformatics·Chao-Gan YanYu-Feng Zang
Apr 20, 2016·Human Brain Mapping·Amber M LeaverJosef P Rauschecker
Feb 9, 2017·Frontiers in Human Neuroscience·Yu-Chen ChenXindao Yin

❮ Previous
Next ❯

Citations

Jul 28, 2020·Frontiers in Neuroscience·Yuexin CaiYiqing Zheng
Mar 13, 2020·Frontiers in Human Neuroscience·Shirui ChengFanrong Liang
Jul 21, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·I D StulinI V Damulin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.