Disrupted posterior cingulate-amygdala connectivity in postpartum depressed women as measured with resting BOLD fMRI

Social Cognitive and Affective Neuroscience
Henry W ChaseMary L Phillips


Disengagement of emotion regulation circuits was previously shown in depressed mothers and was hypothesized to underlie the impaired maternal-infant sensitivity described in postpartum depression (PPD). We hypothesized similarly reduced resting-state functional connectivity in default mode network (DMN) regions involved in social cognition in PPD. Resting-state functional MRI, clinical and mother-infant attachment data were obtained from 14 unmedicated postpartum women with major depression and 23 healthy postpartum women. Posterior cingulate cortex (PCC) time series were extracted, filtered between 0.007 and 0.08 Hz and used as regressors in a whole brain general linear model analysis. PCC-right amygdala connectivity was significantly disrupted in depressed compared to healthy mothers for low-frequency neural activity, showing a negative (inverse) coupling in the depressed group but not in the controls. PCC-right amygdala connectivity was positively correlated with PCC-parahippocampus connectivity. Resting connectivity patterns of positive co-activations in postpartum women mirrored the canonical DMN. These findings of reduced PCC-amygdala coupling raise the possibility that PPD might involve the disruption of outward, prevent...Continue Reading


Jun 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·J L CoxR Sagovsky
Feb 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·P V Trad
Nov 14, 2000·Archives of General Psychiatry·M W O'HaraA Wenzel
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Aug 18, 2004·Biological Psychiatry·Ellen LeibenluftJames V Haxby
Oct 22, 2004·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Ramona T Mercer
Feb 8, 2005·American Journal of Obstetrics and Gynecology·Zachary N StoweD Jeffrey Newport
Nov 2, 2005·Obstetrics and Gynecology·Norma I GavinTammeka Swinson
Mar 23, 2006·JAMA : the Journal of the American Medical Association·Myrna M WeissmanUNKNOWN STAR*D-Child Team
Jul 21, 2006·Journal of Clinical Psychopharmacology·Katherine L WisnerEydie L Moses-Kolko
Mar 16, 2007·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Ruth Feldman
May 4, 2007·NeuroImage·Jason L SteinAndreas Meyer-Lindenberg
Nov 7, 2007·CNS Spectrums·Michael E SilvermanMartin Goldstein
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
May 20, 2008·Journal of Neuroscience Methods·René HurlemannMichael X Cohen
Jun 25, 2008·Social Cognitive and Affective Neuroscience·Marcia K JohnsonSusan Nolen-Hoeksema
Sep 6, 2008·Journal of Child Psychology and Psychiatry, and Allied Disciplines·James E SwainJames F Leckman
Jan 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthias BeckmannMatthew F S Rushworth
Apr 3, 2009·Journal of Neurophysiology·Michael D FoxMarcus E Raichle
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marieke L SchölvinckDavid A Leopold
May 14, 2010·Journal of Neurophysiology·Jessica R Andrews-HannaRandy L Buckner
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yvette I ShelineMark A Mintun
Sep 22, 2010·Social Cognitive and Affective Neuroscience·Marc G BermanJohn Jonides
Oct 12, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jennifer Barrett, Alison S Fleming
Feb 19, 2011·Cerebral Cortex·Philipp G SämannMichael Czisch
Apr 20, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Pilyoung KimJames E Swain
Aug 23, 2011·Progress in Brain Research·Linda J Larson-PriorSteven E Petersen
Sep 2, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shir AtzilRuth Feldman
Sep 6, 2011·NeuroImage·Xiaoqian J ChaiSusan Whitfield-Gabrieli
Jun 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Charlotte PrévostJohn P O'Doherty
Jun 28, 2012·Frontiers in Human Neuroscience·Rogier B MarsMatthew F S Rushworth

❮ Previous
Next ❯


Sep 1, 2015·Hormones and Behavior·Susanne Brummelte, Liisa A M Galea
Dec 19, 2015·Social Neuroscience·Kathleen E WonchAlison S Fleming
Jul 26, 2014·Journal of Neuroendocrinology·A DobolyiD S Stolzenberg
Sep 7, 2016·Behavioural Brain Research·Benjamin C NephewJean A King
Oct 21, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Patrick MacDonald FisherVibe Gedsoe Frokjaer
Jan 4, 2017·PloS One·Gianluca EspositoMarc H Bornstein
Apr 6, 2018·Cognitive, Affective & Behavioral Neuroscience·Chaohui GuoAlison E Hipwell
Nov 2, 2017·Scientific Reports·Elisabeth C CaparelliYihong Yang
Feb 18, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michelle SilverKristina M Deligiannidis
May 21, 2019·Journal of Neuroendocrinology·Alexander J DuffordPilyoung Kim
May 3, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Archana AsundiNina H Lin
Jul 26, 2014·Journal of Neuroendocrinology·E L Moses-KolkoJ E Swain
Feb 15, 2017·Proceedings of the National Academy of Sciences of the United States of America·Shir AtzilLisa Feldman Barrett
May 19, 2018·Frontiers in Psychology·Jin-Xia ZhengJian-Ping Gu
Jul 17, 2018·Archives of Women's Mental Health·Erika Barba-MüllerElseline Hoekzema
Apr 10, 2019·Infant Mental Health Journal·Ingrid GeerlingAnne Sved Williams
Sep 10, 2020·Frontiers in Psychology·Ning MaoHaixia Ji
Jan 4, 2019·Journal of Affective Disorders·Susanne StickelNatalia Chechko
May 4, 2021·Human Brain Mapping·Yunjin BakNa-Young Shin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.