Disrupted regulatory T cell homeostasis in inflammatory bowel diseases

World Journal of Gastroenterology : WJG
Christophe PedrosMarianne Chabod

Abstract

In the gut, where billions of non-self-antigens from the food and the microbiota are present, the immune response must be tightly regulated to ensure both host protection against pathogenic microorganisms and the absence of immune-related pathologies. It has been well documented that regulatory T cells (Tregs) play a pivotal role in this context. Indeed, Tregs are able to prevent excessive inflammation, which can lead to the rupture of intestinal homeostasis observed in inflammatory bowel diseases (IBDs). Both the worldwide incidence and prevalence of such diseases have increased throughout the latter part of the 20(th) century. Therefore, it is crucial to understand how Tregs suppress the colitogenic immune cells to establish new treatments for patients suffering from IBDs. In this review, we will first summarize the results obtained in animal model studies that highlight the importance of Tregs in maintaining intestinal homeostasis and describe the specific suppressive mechanisms involved. Next, our current knowledge about Tregs contribution to human IBDs will be reviewed, as well as the current therapeutic perspective on using Tregs for clinical IBD treatment and the challenges that remain to be resolved to ensure both the s...Continue Reading

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Citations

Mar 2, 2016·The Journal of Experimental Medicine·Rosita RigoniBarbara Cassani
Nov 12, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Jolan E WalterMegan A Cooper
Apr 10, 2017·Digestive Diseases and Sciences·Bo CaoLiu Hong
Jan 11, 2017·Journal of Gastroenterology and Hepatology·Jun Tao LuZhi Hua Ran
Sep 25, 2017·PLoS Pathogens·Eva PastilleAstrid M Westendorf
Jul 14, 2018·Medicines·Ranmali Ranasinghe, Rajaraman Eri
Nov 10, 2017·Mediators of Inflammation·Danilo PagliariRossella Cianci
Aug 7, 2018·Frontiers in Immunology·Janri GeldenhuysMarleen Magdalena Kock
Dec 16, 2020·Inflammatory Bowel Diseases·Niki DafereraAndreas Münch
Dec 22, 2019·Immunology Letters·Su-Ho ParkTae Sung Kim
Apr 15, 2021·Cellular & Molecular Immunology·Jin-Kwan LeeChang-Woo Lee
Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yaoyao ChangHaitao Xiao
May 22, 2019·Inflammatory Intestinal Diseases·Maurizio MarvisiEnrico Maffezzoni

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