Disrupted reward and cognitive control networks contribute to anhedonia in depression

Journal of Psychiatric Research
Liang GongChunming Xie

Abstract

Neuroimaging studies have identified that anhedonia, a core feature of major depressive disorder (MDD), is associated with dysfunction in reward and cognitive control processing. However, it is still not clear how the reward network (β-network) and the cognitive control network (δ-network) are linked to biased anhedonia in MDD patients. Sixty-eight MDD patients and 64 cognitively normal (CN) subjects underwent a resting-state functional magnetic resonance imaging scan. A 2*2 ANCOVA analysis was used to explore the differences in the nucleus accumbens-based, voxelwise functional connectivity (FC) between the groups. Then, the β- and δ-networks were constructed, and the FC intensities were compared within and between theβ- and δ-networks across all subjects. Multiple linear regression analyses were also employed to investigate the relationships between the neural features of the β- and δ-networks and anhedonia in MDD patients. Compared to the CN subjects, the MDD patients showed synergistic functional decoupling in both the β- and δ-networks, as well as decreased FC intensities in the intra- and inter- β- and δ-networks. In addition, the FC in both the β- and δ-networks was significantly correlated with anhedonia severity in the ...Continue Reading

Citations

Sep 12, 2019·Social Cognitive and Affective Neuroscience·Shiyu ZhouYa Zheng
Sep 16, 2020·Molecular Psychiatry·Anahit MkrtchianCarlos A Zarate
Apr 10, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A O Kibitov, G E Mazo
Aug 2, 2021·Psychiatry Research·Angela PisoniMoria Smoski

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