Disrupted Spontaneous Neural Activity Related to Cognitive Impairment in Postpartum Women

Frontiers in Psychology
Jin-Xia ZhengJian-Ping Gu

Abstract

Purpose: Prior research has demonstrated that the postpartum period is associated with an increased risk of cognitive impairment. This study aims to investigate whether disrupted spontaneous neural activity exists in postpartum women without depression using resting-state functional magnetic resonance imaging (rs-fMRI) and to detect the relationship between these abnormalities and cognitive impairment. Materials and Methods: Postpartum women (n = 22) were compared with age- and education-matched nulliparous women (n = 23) using rs-fMRI. We calculated the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) values to evaluate spontaneous neural activity and detect the relationship between rs-fMRI data and cognitive performance. Results: Relative to nulliparous women, postpartum women had significantly decreased ALFF and ReHo values primarily in the left posterior cingulate cortex (PCC) and prefrontal cortex and increased ALFF values in left cerebellar posterior lobe. We found a positive correlation between the ALFF and ReHo values in the PCC and the complex figure test (CFT)-delayed scores in postpartum women (r = 0.693, p = 0.001; r = 0.569, p = 0.011, respectively). Moreover, the clock-drawing test (CD...Continue Reading

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Citations

Dec 11, 2019·Social Cognitive and Affective Neuroscience·Emilia F CárdenasKathryn L Humphreys
Dec 6, 2021·Neuroscience and Biobehavioral Reviews·Jodi L PawluskiJoseph S Lonstein

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Software Mentioned

ALFF
REST
ReHo
SPSS
SPM8
fMRI
rs
VBM
Data Processing Assistant for Resting - State fMRI ( DPARSF )

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