Disrupted Structural and Functional Networks and Their Correlation with Alertness in Right Temporal Lobe Epilepsy: A Graph Theory Study

Frontiers in Neurology
Wenyu JiangJinou Zheng

Abstract

Previous studies have shown that temporal lobe epilepsy (TLE) involves abnormal structural or functional connectivity in specific brain areas. However, limited comprehensive studies have been conducted on TLE associated changes in the topological organization of structural and functional networks. Additionally, epilepsy is associated with impairment in alertness, a fundamental component of attention. In this study, structural networks were constructed using diffusion tensor imaging tractography, and functional networks were obtained from resting-state functional MRI temporal series correlations in 20 right temporal lobe epilepsy (rTLE) patients and 19 healthy controls. Global network properties were computed by graph theoretical analysis, and correlations were assessed between global network properties and alertness. The results from these analyses showed that rTLE patients exhibit abnormal small-world attributes in structural and functional networks. Structural networks shifted toward more regular attributes, but functional networks trended toward more random attributes. After controlling for the influence of the disease duration, negative correlations were found between alertness, small-worldness, and the cluster coefficient....Continue Reading

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Citations

Jan 19, 2018·Acta Neurologica Scandinavica·K M ParkS E Kim
Dec 12, 2020·Seizure : the Journal of the British Epilepsy Association·Tianyu ZhangTianhua Yang
Sep 2, 2018·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Ashish Raj, Fon Powell

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Software Mentioned

rTLE
PANDA
SPM8
GRETNA
Matlab
Prime
SPSS

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