Disrupted thalamic resting-state functional networks in schizophrenia

Frontiers in Behavioral Neuroscience
Hsiao-Lan Sharon WangRongjun Yu

Abstract

The thalamus plays a key role in filtering or gating information and has extensive interconnectivity with other brain regions. Recent studies provide evidence of thalamus abnormality in schizophrenia, but the resting functional networks of the thalamus in schizophrenia is still unclear. We characterize the thalamic resting-state networks (RSNs) in 72 patients with schizophrenia and 73 healthy controls, using a standard seed-based whole-brain correlation. In comparison with controls, patients exhibited enhance thalamic connectivity with bilateral precentral gyrus, dorsal medial frontal gyrus, middle occipital gyrus, and lingual gyrus. Reduced thalamic connectivity in schizophrenia was found in bilateral superior frontal gyrus, anterior cingualte cortex, inferior parietal lobe, and cerebellum. Our findings question the "disconnectivity model" of schizophrenia by showing the over-connected thalamic network during resting state in schizophrenia and highlight the thalamus as a key hub in the schizophrenic network abnormality.

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Citations

Jul 6, 2016·Frontiers in Human Neuroscience·Anne GierschPhilippe Isope
Aug 18, 2016·Schizophrenia Research·Monica Giraldo-Chica, Neil D Woodward
Jun 4, 2019·Journal of Psychopharmacology·Yuliya ZaytsevaTomáš Páleníček
Apr 27, 2017·Brain Imaging and Behavior·Kristina C SkåtunLars T Westlye
May 12, 2020·Frontiers in Neuroscience·Thomas T Liu, Maryam Falahpour
Dec 20, 2020·NeuroImage. Clinical·Adam J CulbrethJames A Waltz
Mar 16, 2021·Psychological Medicine·Susanna L FryerDaniel H Mathalon

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