Disrupted tongue microbiota and detection of nonindigenous bacteria on the day of allogeneic hematopoietic stem cell transplantation

PLoS Pathogens
Saori OkuYoshihisa Yamashita

Abstract

Disruption of the intestinal microbiota caused by intensive chemotherapy, irradiation and antibiotics can result in development of severe gut graft-versus-host disease and infectious complications, leading to poorer outcomes among allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Although the oral cavity is also densely colonized by indigenous microorganisms, the bacterial composition in allo-HSCT recipients remains unclear. We determined the tongue microbiota composition of 45 patients with hematological disorders on the day of transplantation and compared them to 164 community-dwelling adults. The V1-V2 regions of the 16S rRNA gene sequences demonstrated that the allo-HSCT recipients had less diverse and distinct microbiota from that of community-dwelling adults. The full-length 16S rRNA gene sequences identified 146 bacterial taxa in the microbiota of allo-HSCT recipients, of which 34 bacterial taxa did not correspond to bacteria primarily inhabiting the oral cavity deposited in the expanded Human Oral Microbiome Database. Notably, the detection of Staphylococcus haemolyticus and/or Ralstonia pickettii was significantly associated with a higher risk of mortality during the follow-up period. These res...Continue Reading

References

Jul 2, 2003·Journal of Clinical Periodontology·Donna L MagerSigmund S Socransky
Dec 8, 2005·Applied and Environmental Microbiology·Catherine Lozupone, Rob Knight
Jan 31, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·I StelzmuellerH Bonatti
Apr 28, 2006·The New England Journal of Medicine·Edward A Copelan
Jan 21, 2009·Periodontology 2000·Gunnar Dahlén
Feb 20, 2010·Nature Reviews. Cancer·Robert R Jenq, Marcel R M van den Brink
Jul 14, 2010·Database : the Journal of Biological Databases and Curation·Tsute ChenFloyd E Dewhirst
Jan 11, 2012·Clinical Microbiology Reviews·Joanna S Brooke
Jun 22, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ying TaurEric G Pamer
Jan 16, 2013·Genome Biology·Yanjiao ZhouGeorge M Weinstock
Jul 9, 2014·Annual Review of Microbiology·Daria Van Tyne, Michael S Gilmore
Sep 14, 2015·Microbiology·Tomasz CzekajEligia M Szewczyk
Feb 26, 2016·Scientific Reports·Toru TakeshitaYoshihisa Yamashita
Apr 14, 2016·PeerJ·Patrick D SchlossSarah K Highlander
May 15, 2016·Trends in Molecular Medicine·Simone BecattiniEric G Pamer
May 24, 2016·Nature Methods·Benjamin J CallahanSusan P Holmes
Nov 16, 2016·BMC Microbiology·Josef WagnerJulian Parkhill
Mar 16, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jonathan U PeledMarcel R M van den Brink
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonathan L GolobDavid N Fredricks
Jun 18, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yasuo MoriToshihiro Miyamoto
Aug 17, 2018·MSphere·Mikari AsakawaYoshihisa Yamashita
Nov 24, 2018·Blood Reviews·Edward A CopelanBelinda R Avalos

❮ Previous
Next ❯

Citations

Jan 9, 2021·Expert Opinion on Biological Therapy·Chia-Chi ChangRobert R Jenq
Jan 28, 2021·Current Tropical Medicine Reports·Berenice Morales-FrancoClaudia Lisette Charles-Niño
Feb 4, 2021·International Journal of Molecular Sciences·Riccardo MasettiAndrea Pession
Jan 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hani Choudhry

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

PacBio Sequel
DADA2
vegan
BLAST
SMRT Link
R
UPARSE

Related Concepts

Related Feeds

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.