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Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis

Scientific Reports

Nov 14, 2019

Wuan-Geok SawGerhard Grüber

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Abstract

The dynamic interaction of the N- and C-terminal domains of mycobacterial F-ATP synthase subunit ε is proposed to contribute to efficient coupling of H+-translocation and ATP synthesis. Here, we investigate crosstalk between both subunit ε domains by introducing chromosomal atpC missens...read more

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Adenosine Triphosphate
Antibiotics
Carbon
Cell Wall
Chromosomes
Energy Metabolism
Metabolism
Genus Mycobacterium
Oxidative Phosphorylation
Intracellular
4
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Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis

Scientific Reports

Nov 14, 2019

Wuan-Geok SawGerhard Grüber

PMID: 31727946

DOI: 10.1038/s41598-019-53107-3

Abstract

The dynamic interaction of the N- and C-terminal domains of mycobacterial F-ATP synthase subunit ε is proposed to contribute to efficient coupling of H+-translocation and ATP synthesis. Here, we investigate crosstalk between both subunit ε domains by introducing chromosomal atpC missens...read more

Mentioned in this Paper

Adenosine Triphosphate
Antibiotics
Carbon
Cell Wall
Chromosomes
4

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