Jun 25, 2016

Disrupting dorsolateral prefrontal cortex by rTMS reduces the P300 based marker of deception

BioRxiv : the Preprint Server for Biology
Inga KartonTalis Bachmann


It is well known that electroencephalographic event related potential component P300 is sensitive to perception of critical items in a concealed information test. However, it is not known whether the relative level of expression of P300 as a neural marker of deception can be manipulated by means of non-invasive neuromodulation. Here, we show that while P300 exhibited systematic amplitude differences in response to the more as well as the less significant stimuli items encountered at the crime scene compared to neutral items, offline rTMS to dorsolateral prefrontal cortex attenuated P300 amplitude in response to the critical items. Yet, the individual subjects showed different sensitivity of the P300 as the marker of concealment. We conclude that rTMS can be used for subduing electrophysiological markers of deception, but this effect depends on whether the subject belongs to the group of CIT-sensitive individuals.

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Mentioned in this Paper

Biological Markers
EP300 protein, human
Prefrontal Cortex
EP300 gene
Transcranial Magnetic Stimulation, Repetitive
Potentials, Event-Related
Prefrontal Cortex (Walker)

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