Disruption of Broca's Area Alters Higher-order Chunking Processing during Perceptual Sequence Learning

Journal of Cognitive Neuroscience
Andrea AlamiaAlexandre Zénon

Abstract

Because Broca's area is known to be involved in many cognitive functions, including language, music, and action processing, several attempts have been made to propose a unifying theory of its role that emphasizes a possible contribution to syntactic processing. Recently, we have postulated that Broca's area might be involved in higher-order chunk processing during implicit learning of a motor sequence. Chunking is an information-processing mechanism that consists of grouping consecutive items in a sequence and is likely to be involved in all of the aforementioned cognitive processes. Demonstrating a contribution of Broca's area to chunking during the learning of a nonmotor sequence that does not involve language could shed new light on its function. To address this issue, we used offline MRI-guided TMS in healthy volunteers to disrupt the activity of either the posterior part of Broca's area (left Brodmann's area [BA] 44) or a control site just before participants learned a perceptual sequence structured in distinct hierarchical levels. We found that disruption of the left BA 44 increased the processing time of stimuli representing the boundaries of higher-order chunks and modified the chunking strategy. The current results hig...Continue Reading

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Citations

Oct 7, 2016·Frontiers in Behavioral Neuroscience·Andrea AlamiaAlexandre Zenon
Oct 10, 2018·PloS One·Feng RongGregory Hickok
Jan 9, 2019·Brain Connectivity·Kiran DhakalMukesh Dhamala
Jan 14, 2017·Frontiers in Human Neuroscience·Masumi Wakita
Aug 19, 2018·Language, Speech, and Hearing Services in Schools·Joanne A DeocampoChristopher M Conway
Aug 6, 2019·Frontiers in Psychology·Claudio BrozzoliMartin Lövdén
Nov 2, 2019·Current Opinion in Neurobiology·József Fiser, Gábor Lengyel
May 19, 2020·NeuroImage·David M BashwinerRex E Jung
Feb 18, 2016·Learning & Memory·Oleg SolopchukAlexandre Zénon

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