Disruption of central and peripheral circadian clocks in police officers working at night

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Anna KoshyDiane B Boivin

Abstract

Working atypical schedules leads to temporal misalignments between a worker's rest-activity cycle and their endogenous circadian system. Several studies have reported disturbed centrally controlled rhythms, but little is known on shift workers' peripheral clocks. Here, we assessed central clock markers, urinary 6-sulfatoxymelatonin and salivary cortisol, and clock gene expression in 2 peripheral clocks, oral mucosa cells and peripheral blood mononuclear cells (PBMCs), in 11 police officers. Before working 7 consecutive nights, officers' centrally controlled rhythms were aligned to a day-oriented schedule. These rhythms were partially realigned to the shifted schedule and dampened after a week working nights. For peripheral clocks at baseline, Period (PER)1-3 and nuclear receptor subfamily 1, group D, member 1 (REV-ERBα) in oral mucosa cells had a significant mRNA peak in the afternoon, whereas in PBMCs, higher PER1-3 expression was observed at 10:00 compared with 19:30. After a week working nights, PER1-3 and REV-ERBα expression in oral mucosa cells lost rhythmicity, and in PBMCs, the morning/evening difference observed at baseline was lost. To our knowledge, this is the first study to demonstrate the disruption of several peri...Continue Reading

References

Oct 27, 1998·Chronobiology International·R Y Moore, R Silver
Oct 3, 1999·Annals of Internal Medicine·N C NetzerK P Strohl
Dec 6, 2002·Journal of Biological Rhythms·Diane B Boivin, Francine O James
Jun 5, 2003·Journal of the National Cancer Institute·Eva S SchernhammerGraham A Colditz
Jan 14, 2005·Chronobiology International·Francine O JamesDiane B Boivin
Apr 7, 2005·Journal of the National Cancer Institute·Elisabeth FilipskiFrancis Lévi
Aug 13, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Michèle TeboulGérard Milano
Nov 4, 2005·Journal of Biological Rhythms·Fabienne GuillaumondNicolas Cermakian
Apr 6, 2006·Cancer Causes & Control : CCC·Scott Davis, Dana K Mirick
May 10, 2006·Genes, Brain, and Behavior·H Oster
Oct 7, 2006·Annals of Clinical Biochemistry·Debra J Skene, Josephine Arendt
Mar 14, 2008·Neuroscience Research·Hiroaki KusanagiKazuo Mishima
Feb 5, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Kevin J EmersonChristina M Holzapfel
Nov 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Christopher VollmersSatchidananda Panda
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Makoto AkashiKoichi Node
Apr 2, 2011·Journal of Biological Rhythms·Nicolas CermakianDiane B Boivin
Mar 1, 2012·Occupational and Environmental Medicine·Beata PeplonskaWojciech Wasowicz
Apr 10, 2012·Annual Review of Neuroscience·Jennifer A MohawkJoseph S Takahashi
May 4, 2012·Scandinavian Journal of Work, Environment & Health·Edyta ReszkaWojciech Wasowicz
May 15, 2012·Current Biology : CB·Till RoennebergCéline Vetter
May 25, 2012·Chronobiology International·Diane B BoivinN M K Ng Ying Kin
Jan 10, 2014·Scandinavian Journal of Work, Environment & Health·Massimo BracciLory Santarelli
Dec 17, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marc CuestaDiane B Boivin
Jun 3, 2015·The Canadian Journal of Cardiology·Faisal J AlibhaiTami A Martino
Feb 14, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marc CuestaDiane B Boivin
Mar 17, 2016·Advances in Nutrition·Jonathan D JohnstonFred W Turek
Apr 30, 2016·International Journal of Molecular Sciences·Massimo BracciLory Santarelli
Nov 28, 2016·Cancer Cell·Nicole M KettnerLoning Fu
Feb 16, 2017·BMC Biology·Silke KiesslingNicolas Cermakian
Jun 6, 2017·Current Biology : CB·Sophie M T WehrensJonathan D Johnston
May 8, 2018·Proceedings of the National Academy of Sciences of the United States of America·Laura KervezeeDiane B Boivin

❮ Previous
Next ❯

Citations

Jun 17, 2020·The Journal of Physiology·Denise KemlerKaryn A Esser
Dec 5, 2019·Scientific Reports·Bette LoefDebbie van Baarle
May 14, 2020·AIDS Research and Therapy·Jing OuyangJean-Pierre Routy
Jan 17, 2020·JCI Insight·Jeffrey A HaspelLaura A Solt
Oct 28, 2019·Journal of Circadian Rhythms·Kamila WeissováJana Kopřivová
Oct 22, 2020·Journal of Occupational and Environmental Medicine·Andrée-Anne LavigneLuc Laberge
Dec 17, 2020·Physiology·Sandra CrnkoLinda W van Laake
Feb 13, 2021·Science·Kevin B Koronowski, Paolo Sassone-Corsi
May 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jan-Frieder HarmsenPatrick Schrauwen
Jul 22, 2021·Scientific Reports·Jonathan TylerMargit Burmeister
Jan 1, 2022·Journal of Biological Rhythms·Diane B BoivinAnastasi Kosmadopoulos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Marc CuestaDiane B Boivin
The Journal of Immunology : Official Journal of the American Association of Immunologists
Marc CuestaDiane B Boivin
Schizophrenia Research
Anne-Sofie JohanssonGabriella B Lundkvist
© 2022 Meta ULC. All rights reserved